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Abstract
The distributions of plasma total cholesterol, apolipoproteins A-I and B and lipoprotein(a)
levels as well as genetic typings of apolipoprotein(a) and apolipoprotein E were determined
in a randomly selected sample of American Black women (mean age 22.2 ± 6.5 years).
Mean plasma levels of cholesterol, apolipoprotein A-I, apolipoprotein B and lipoprotein(a)
were 184.5 ± 3.0 mg/dl, 138.0 ± 3.1 mg/dl, 79.5 ± 1.8 mg/dl and 24.5 ± 1.5 mg/dl,
respectively. Plasma lipoprotein (a) levels correlated significantly with apolipoprotein
B and cholesterol. The contribution of apolipoprotein (a) and apolipoprotein E polymorphisms
in affecting these quantitative traits was evaluated. The apolipoprotein(a) locus
was extremely polymorphic with 27 alleles, while the 3 common alleles were observed
in the apolipoprotein E gene. The frequencies of the APOE∗2, APOE∗3 and APOE∗4 alleles were 0.094, 0.674 and 0.232, respectively. An inverse relationship was
observed between the size of apolipoprotein(a) isoforms and lipoprotein(a) levels
(r = 0.37; P = 0.0001). The apolipoprotein E polymorphism revealed a significant genotypic effect
on apolipoprotein B (P = 0.0008) and cholesterol (P = 0.005) levels; these concentrations
were lower in the APOE 2–3 genotype and higher in the 3–4 and 4–4 genotypes compared
with the common 3–3 genotype. The apolipoprotein E polymorphism explained 15.8% and
6.3% of the phenotypic variance in apolipoprotein B and cholesterol levels, respectively.
This study demonstrates that genetics play an important role in determining quantitative
risk factors for coronary heart disease among American Black women.
Keywords
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References
- Apolipoprotein E polymorphism and atherosclerosis.Arteriosclerosis. 1988; 8: 21
- The mysteries of lipoprotein(a).Science. 1989; 146: 910
- Human plasma lipoprotein[a]: structural properties.J Biol Chem. 1983; 258: 4589
- Heterogeneity of human lipoprotein(a). Isolation and characterization of the lipoprotein subspecies and their properties.J Biol Chem. 1984; 259: 11478
- The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis.Atherosclerosis. 1986; 62: 257
- Lp(a) lipoprotein as a risk factor for myocardial infarction.J Am Med Assoc. 1986; 256: 2544
- Association of level of lipoprotein Lp(a), plasma lipids and other lipoproteins with coronary artery disease documented by angiography.Circulation. 1986; 74: 765
- Lp(a) lipoprotein as a risk factor for coronary heart disease and cerebral infarction.Atherosclerosis. 1986; 59: 204
- Lipoprotein(a) in ischemic cerebrovascular disease: a new approach to the assessment of risk for stroke.Neurology. 1987; 37: 515
- Apolipoproteins(a), AI, and B and parental history in men with early onset ischemic heart disease.Lancet. 1988; i: 1075
- Lipoprotein Lp(a). A risk factor for myocardial infarction.Arteriosclerosis. 1988; 8: 401
- Lipoprotein (a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men.Br Med J. 1990; 301: 1251
- Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age.Clin Chem. 1990; 36: 23
- The relation of lipoprotein[a] concentrations and apolipoprotein[a]phenotypes with a symptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study.Arteriosclerosis Thromb. 1993; 13: 1566
- Lipoprotein(a) levels and risk of coronary heart disease in men. The Lipid Research Clinics Coronary Primary Prevention Trial.J Am Med Assoc. 1994; 271: 1003
- The genetics of the Lp antigen. II. A family study and proposed models of genetic control.Ann Hum Genet. 1974; 38: 56
- Genetics of coronary heart disease.in: 2nd Ed. Progress in Medical Genetics. Vol. V. W.B. Saunders, Philadelphia, PA1983: 35-90
- The genetics of quantitative plasma Lp(a): analysis of a large pedigree.Am J Med Genet. 1983; 16: 188
- Genetics of the Lp lipoprotein in Japanese-Americans.Genet Epidemiol. 1985; 2: 121
- Three alleles for quantitative Lp(a).Genet Epidemiol. 1986; 3: 53-55
- Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.Am J Hum Genet. 1992; 5: 840
- Polymorphic forms of human apolipoprotein[a]: inheritance and relationship of their molecular weights to plasma levels of lipoprotein[a].J Lipid Res. 1990; 31: 613
- Molecular basis of apolipoprotein(a) isoform size heterogeneity as revealed by pulsed-field gel electrophoresis.J Clin Invest. 1991; 87: 2161
- Expressed hypervariable polymorphism of apolipoprotein(a).Am J Hum Genet. 1991; 49: 1084
- Identification of 34 apolipoprotein(a) isoforms: different expression of apolipoprotein(a) alleles between American Blacks and Whites.Biochem Biophys Res Commun. 1993; 191: 1196
- Genetics of the Lp(a) lipoprotein trait. I. Relation of Lp(a) glycoprotein phenotypes to Lp(a) lipoprotein concentrations in plasma.Hum Genet. 1988; 78: 46
- Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a) lipoprotein concentrations in plasma.J Clin Invest. 1987; 80: 465
- Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups.Hum Genet. 1991; 86: 614
- Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentration.J Clin Invest. 1992; 90: 60
- Relationship of plasma lipoprotein Lp(a) levels to race and to apolipoprotein B.Arteriosclerosis. 1985; 5: 272
- Black-white differences in serum Lp(a) levels.Clin Chim Acta. 1987; 167: 31
- Lipoprotein(a) levels in black and white children and adolescents with IDDM.Diabetes Care. 1991; 14: 287
- Racial (black-white) differences in serum lipoprotein(a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study.Circulation. 1991; 84: 167
- Lipoprotein[a] concentrations and apolipoprotein[a] phenotypes in Caucasians and African Americans. The CARDIA Study.Arteriosclerosis Thromb. 1993; 13: 1045
- Contribution of the apo[a] phenotype to plasma Lp[a] concentrations shows considerable ethnic variation.J Lipid Res. 1991; 32: 1928
- Hypervariable polymorphism of APO(a) in Blacks and Whites as reflected by phenotyping.Chem Phys Lipids. 1994; 67/68: 292
- The relationship of APOE polymorphism and cholesterol levels in normoglycemic and diabetic subjects in a biethnic population from the San Luis Valley, Colorado.Atherosclerosis. 1994; 112: 145-159
- Enzymatic determination of total serum cholesterol.Clin Chem. 1974; 20: 475
- Statistics.CBS College Publishing, New York1981
- The Analysis of Variance.in: John Wiley & Sons, New York1959: 221-235
- Applied Statistical Models.R.D. Irwin, Homewood, IL1990
- Serum lipoprotein(a) levels in elderly black and white men in the Charleston Heart Study.Clin Genet. 1993; : 231
- The Negroes of Charleston (S.C.); a study of hemoglobin types, serology, and morphology.Am J Phys Anthropol. 1958; 16: 264
- Isolation and characterization of two sub-species of Lp(a), one containing apoE and one free of apoE.Biochim Biophys Acta. 1992; 1127: 130
- Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks.Dis Markers. 1989; 7: 55
- Apolipoprotein E polymorphism and its association with serum lipoprotein concentrations in blacks versus white children: The Bogalusa Heart Study.Metabolism. 1993; 42: 386
- The influence of apolipoprotein E genotypes on plasma lipoprotein(a) levels in Singapore Chinese.Am J Hum Genet. 1993; 53 (abstr): 813
- Apolipoprotein E polymorphism affects plasma levels of lipoprotein(a).Atherosclerosis. 1991; 90: 174
- Effect of one year treatment with pravastatin, an HMG-COA reductase inhibitor, on lipoprotein(a).J Clin Pharmacol. 1993; 33: 580
Article info
Publication history
Accepted:
March 1,
1995
Received in revised form:
January 17,
1995
Received:
November 15,
1994
Identification
Copyright
© 1995 Published by Elsevier Inc.
