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Abstract
The aim of this study was to determine blood lymphocyte T subset counts in children
with elevated levels of low-density lipoprotein cholesterol. We studied 107 children,
ages 2.0 to 15.9 years, from 79 families who were referred to our Lipid Research Clinic
because total cholesterol serum levels higher than 200 mg/dl had been detected in
at least one child. At the time of diagnosis we analyzed serum lipoprotein profile
and blood lymphocyte T subsets (CD3, CD4 and CD8). Children were classified according
to LDL-C levels into three groups: (1) normal, if levels were between the 5th and
75th percentiles (50 and 125 mg/dl, respectively); (2) at moderate risk, if levels
were between the 75th and 95th percentiles (125 and 150 mg/dl, respectively); and
(3) at high risk, if levels were above the 95th percentile (150 mg/dl). In children
aged 2.0 to 6.9 years, all lymphocyte T subset counts were higher in the high risk
group than in the normal group (P < 0.05 and P < 0.01). In children aged 11.0 to 15.9 years, the CD4 subset count was also significantly
higher in the high risk group than in the other two groups (P < 0.05 and P < 0.01). These results are in agreement with pathologic findings in the atheromatous
plaque.
Keywords
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References
- The pathogenesis of atherosclerosis: a perspective for the 1990s.Nature. 1993; 362: 801
- Immune and inflammatory mechanisms in the development of atherosclerosis.Br Heart J. 1993; 69: S38
- Regional accumulation of T cells, macrophages and smooth muscle cells in the human atherosclerotic plaque.Arteriosclerosis. 1986; 6: 131
- Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.Am J Pathol. 1986; 125: 191
- Atherosclerotic lesions in humans. In situ immunophenotypic analysis suggesting an immune mediated response.Lab Invest. 1992; 61: 166
- An immunohistochemical analysis of human aortic fatty streaks.Hum Pathol. 1987; 18: 375
- Immunoglobulins, complement components and lymphocyte subsets are related to plasma lipoproteins in healthy children.Atherosclerosis. 1992; 93: 157
- Enzymatic determination of total serum cholesterol.Clin Chem. 1974; 20: 470
- Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide.Clin Chem. 1982; 28: 2077
- Comparison of improved precipitation methods for quantification of high-density lipoprotein cholesterol.Clin Chem. 1985; 31: 217
- Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge.Clin Chem. 1972; 18: 499
- Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry.Cytometry. 1990; 11: 453
- Age-related changes in human blood lymphocyte subpopulations.J Pediatr. 1992; 120: 216
- Age-related changes in human blood lymphocyte subpopulations. II. Varying kinetics of percentage and absolute count measurements.Clin Immunol Immunopathol. 1994; 70: 152
- Usefulness of serum apolipoprotein B levels for screening children with primary dyslipoproteinemias.Am J Dis Child. 1992; 146: 1230
- Cardiología, Pediatría, Nutrición y Medicina Preventiva, Informe sobre el colesterol en niños y adolescentes españoles.Clin Invest Arteriosclerosis. 1991; 3: 47
- Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis: The Bogalusa Heart Study.N Engl J Med. 1986; 314: 138
- T lymphocytes in aortic and coronary intimas. Their potential role in atherogenesis.Am J Pathol. 1988; 130: 369
- Serum C4 concentration and risk of atherosclerosis.Br Med J. 1994; 309: 1087
- Serum bilirubin concentrations in children at risk for atherosclerosis.Clin Chem. 1994; 40: 1791
Article info
Publication history
Accepted:
March 10,
1995
Received in revised form:
February 3,
1995
Received:
August 5,
1994
Identification
Copyright
© 1995 Published by Elsevier Inc.
