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Microalbuminuria is thought to be a predictor of cardiovascular disease (CVD). A high prevalence of micro-albuminuria might therefore be expected in patients with homozygous familial hypercholesterolaemia (HFH), as they develop severe premature atherosclerosis. We tested for this in 15 HFH patients (M = 9, F = 6; mean age 19.3 years). Urinary albumin excretion rates (UAER) were normal in all patients. In addition, there was no difference in the mean UAER between those with documented CVD (n = 8; UAER = 5.17 μg/min) and those without (n = 7; UAER = 3.60 μg/min). There is therefore no association between microalbuminuria and CVD in HFH.
Received: June 7, 1995
© 1995 Published by Elsevier Inc.