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Abstract
A high intake of trans fatty acids (TFAs) has been shown to have an undesirable effect on serum lipid profiles
and lipoprotein(a) (Lp(a)) levels and may thereby increase the risk for coronary heart
disease (CHD). We performed a study in CHD patients, and measured the TFA concentration
of the plasma phospholipid fraction. Comparison was made between a case group with
angiographically documented severe CHD (>80% stenosis in one coronary vessel, n = 83) and a control group of patients who had just minor stenosis on the coronary
angiography (<50% stenosis in all three major vessels, n = 78). All subjects were under 68 years of age and were prestratified on age, gender
and smoking habits. The two groups were comparable according to the prestratification
criteria, body mass index, blood pressure, number of cigarettes smoked and total fat
intake. Controls had higher plasma HDL levels (P < 0.001) and lower, albeit not significantly lower, (P = 0.07) plasma LDL levels. No significant correlations were found between percentages
of TFAs in plasma phospholipids and plasma LDL or HDL cholesterol levels. Of the major
fatty acid classes, only the percentage of saturated fatty acids was significantly
higher in cases (46.2 ± 0.92%) than in controls (45.8 ± 1.07% (means ± S.D.)). The
difference in total TFA content between cases and controls (0.32 ± 0.02% versus 0.35
± 0.02%) was −0.03% (P = 0.2). For the specific TFAs C16:1n − 7tr, C18:1n − 9tr and C18:2n − 6tr, just minor differences were found. Adjusted odds ratios for tertiles of TFA
percentages were 0.56 (0.25 – 1.23) and 0.76 (0.36 – 1.61) for the highest and middle
tertile compared to the lowest. These findings do not support an association between
TFA intake and risk for coronary heart disease.
Keywords
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Article info
Publication history
Accepted:
May 20,
1996
Received in revised form:
May 17,
1996
Received:
January 10,
1996
Identification
Copyright
© 1996 Published by Elsevier Inc.
