Abstract
Atherosclerotic plaque-like lesions are prevalent in synthetic arteriovenous shunts
created to provide vascular access for hemodialysis. Similarities to atherosclerotic
plaques in native arteries include eccentric location, immunoreactivity for smooth
muscle actin, dystrophic calcifications, superimposed thrombi, and foam cells. Fatty
streaks were not grossly identified on Sudan IV staining. Because of the similarities
to atherosclerosis in native vessels, these findings may have several implications
for atherogenesis. The development of raised, fibrous lesions does not require decades.
The presence of smooth muscle in atherosclerotic plaque-like lesions does not require
a source from tunica media. A precursor fatty streak may not be required for the development
of raised, fibrous lesions. Finally, development of atherosclerotic plaque-like lesions
does not require putative inflammatory effects from cholesterol or LDL accumulation,
or even a native vessel that can respond to injury. The atherosclerotic plaque-like
lesions in this study probably developed from organization of mural thrombi.
Keywords
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Article Info
Publication History
Accepted:
April 30,
2001
Received:
July 19,
2000
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
