Abstract
Aim
The present clinical study tested the hypothesis that oil-rich fish consumption improves
CHD risk factors.
Methods
Forty-eight (16 men) non-obese, healthy adults aged 20–55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers).
Subjects were instructed to maintain dietary and physical activity patterns during
the period of study. Blood pressure, anthropometric, body composition and dietary
information with fasting blood samples to determine traditional and novel CHD risk
markers and plasma fatty acids were obtained before and after each period.
Results
Compared to no-fish, eating salmon significantly decreased systolic, diastolic and
mean arterial blood pressure by 4%, triglycerides by 15%, and LDL-cholesterol by 7%,
and significantly increased HDL-cholesterol by 5% (P < 0.05). The changes in blood pressure and lipids alone with salmon intake predict around
a 25% reduction in CHD risk based on the PROCAM risk calculator. Plasma adiponectin
demonstrated a trend towards improvement (8.39 μmol/L with salmon and 7.52 with no-fish; P = 0.086) but no significant changes were found either in plasma leptin, glucose or insulin
after salmon consumption.
Conclusions
Daily consumption of salmon improves traditional risk predictors of CHD in non-obese
subjects. Adiponectin may be involved but the impact on novel risk factors needs study
in high-risk subjects.
Keywords
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Article info
Publication history
Published online: October 30, 2006
Accepted:
June 14,
2006
Received in revised form:
June 9,
2006
Received:
May 8,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
