Abstract
Objective
Currently no data exists regarding the outcomes after the novel endothelial progenitor
cell capturing stent (EPCcS) placement in bifurcation lesions using a provisional
T-stenting. This study evaluates the 1-year clinical outcome in patients treated with
the EPCcS for a bifurcation lesion using a provisional T-stenting technique and compared
these to a historical control group treated with an identical bare-metal stent (BMS).
Methods
In single-center study, 178 consecutive patients with a de novo bifurcation lesion
treated with an EPCcS and 465 consecutive patients treated with an equivalent BMS
were included. Multivariate and propensity-score analyses were performed to adjust
for differences in clinical and angiographic characteristics between the EPCcS group
and the BMS group.
Results
At 1-year, the cumulative rate of the primary end point (cardiac death, myocardial
infarction (MI), or target lesion revascularization (TLR)) was 12.4% in the EPCcS
group and 17.2% in the BMS group (hazard ratio [HR] 0.70; 95% confidence interval
CI, 0.44–1.12; P = 0.13). The 1-year cumulative rate of TLR was lower among patients treated with EPCcS
compared with the control stent as a result of fewer coronary artery bypass grafting,
10.7% vs. 12% respectively (HR 0.88; 95% CI, 0.53–1.49; P = 0.64). The cumulative rate of definite ST was 0.6% in the EPCcS as compared with 0.4%
in the BMS group.
Conclusions
Although, the EPC stent shows favorable outcomes in the treatment of bifurcation lesions,
the reduction in the cumulative rate of cardiac death, MI, or TLR as compared with
the BMS was statistically non-significant.
Keywords
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Article Info
Publication History
Published online: October 22, 2010
Accepted:
September 19,
2010
Received in revised form:
September 14,
2010
Received:
July 18,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
