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Successful therapy reduces levels of vascular endothelial growth factor (VEGF) in patients with hypertension and patients with hypercholesterolemia

      We read with interest the paper by Sumino et al. [
      • Sumino H.
      • Nakamura T.
      • Ichikawa S.
      • et al.
      Serum levels of vascular endothelial growth factor is decreased by hormone replacement therapy in postmenopausal women without hypercholesterolemia.
      ], who reported the effect of hormone replacement therapy (HRT) on serum levels of vascular endothelial growth factor (VEGF). They suggested that HRT reduced serum levels of VEGF in normocholesterolemic (NC) postmenopausal women (PMW) with hypertension. Conversely, HRT did not affect VEGF serum levels in the PMW with hypercholesterolemia (HC), of whom 74% were treated hypertensives.

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      References

        • Sumino H.
        • Nakamura T.
        • Ichikawa S.
        • et al.
        Serum levels of vascular endothelial growth factor is decreased by hormone replacement therapy in postmenopausal women without hypercholesterolemia.
        Atherosclerosis. 2000; 148: 189-195
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        • et al.
        Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF in clinical disease.
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        • Ambruso D.R.
        • et al.
        In vitro release of vascular endothelial growth factor during platelets aggregation.
        Heart Circ. Physiol. 1998; 44: H1054-H1061
      1. Belgore FM, Lip GYH, McCollum CN, Blann AD. Vascular endothelial growth factor (VEGF) and soluble VEGF receptor (sFlt-1) levels in coronary artery disease and peripheral artery disease. Blood Coag Fibrin 1999;10 (abstract).