The Human Genome Project (HGP) recently completed its first draft sequence of the
human genome [
[1]
]. An additional major aim of this huge endeavour is not only to document the consensus
sequence of all human DNA but also to identify the common genetic variation that is
thought to underlie differences in susceptibility to common diseases [
[2]
]. In the words of Frances Collins, Director of the US National Human Genome Research
Institute ‘virtually all disease, except some trauma, has a hereditary component’.To read this article in full you will need to make a payment
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References
Anon. Human genome projects: work in progress. Nature 2000;405:981.
- New goals for the US Human Genome Project.Science. 1998; 282: 682-689
- Family history of myocardial infarction as an independent risk factor for coronary heart disease.Br. Heart J. 1985; 53: 382-387
- Genetic susceptibility to death from coronary heart disease in a study of twins.New Engl. J. Med. 1994; 330: 1041-1046
Goldstein JL, Brown MS. Familial hypercholesterolaemia. 5th ed. 1983. pp. 672–712.
- Genetic analysis of atherosclerosis: a research paradigm for the common diseases.Hum. Mol. Genet. 1996; 5: 1405-1410
- Patterns of single nucleotide polymorphisms in candidate genes for BP homeostasis.Nature Genetics. 1999; 22: 239-247
- Endothelial nitric oxide.in: Vallance P.J.T Webb D.J Vascular endothelium in human physiology and pathophysiology. Harwood, New York2000: 3-28
- Nitric oxide: physiology, pathophysiology, and pharmacology.Pharmacol. Rev. 1991; 43: 109-142
- Nitric oxide synthase: role in the genesis of vascular disease.Annu. Rev. Med. 1997; 48: 489-509
- Nitric oxide synthases in mammals.Biochem. J. 1994; 298: 249-258
- Expression of human nitric oxide synthase isozymes.Methods. Enzymol. 1996; 268: 449-460
- Exploring vascular nitric oxide in health and disease. The Goulstonian Lecture 1996.J. R. Coll. Physicians Lond. 1997; 31: 321-327
- Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers.J. Hum. Hypertens. 1993; 7: 193-194
- Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.Lancet. 1992; 339: 572-575
- Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium.Lancet. 1987; 2: 1057-1058
- Nitric oxide and prostacyclin. Divergence of inhibitory effects on monocyte chemotaxis and adhesion to endothelium in vitro.Arterioscler. Thromb. 1991; 11: 254-260
- Nitric oxide: an endogenous modulator of leukocyte adhesion.Proc. Natl. Acad. Sci. USA. 1991; 88: 4651-4655
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.J. Clin. Invest. 1989; 83: 1774-1777
- Nitric oxide reversibly inhibits the migration of cultured vascular smooth muscle cells.Circ. Res. 1996; 78: 225-230
- Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis.FEBS Lett. 1993; 334: 170-174
- Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase.Biochem. Biophys. Res. Commun. 1991; 180: 1396-1402
- Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.J. Clin. Invest. 1995; 95: 1747-1755
- Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction.J. Am. Coll. Cardiol. 1994; 24: 1468-1474
- Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.J. Clin. Invest. 1990; 86: 228-234
- Effect of local intra-arterial NG-monomethyl-l-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.J. Hypertens. 1992; 10: 1025-1031
- Selective defect in nitric oxide synthesis may explain the impaired endothelium-dependent vasodilation in patients with essential hypertension.Circulation. 1998; 97: 851-856
- Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension.New Engl. J. Med. 1990; 323: 22-27
- Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.J. Clin. Invest. 1992; 90: 2548-2554
- Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus.J. Am. Coll. Cardiol. 1996; 27: 567-574
- Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults.New Engl. J. Med. 1996; 334 (See comments): 150-154
- Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.Circulation. 1993; 88: 2149-2155
- l-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.J. Clin. Invest. 1992; 90: 1248-1253
- Oral l-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.J. Clin. Invest. 1996; 97: 1989-1994
- Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.J. Clin. Invest. 1997; 99: 41-46
- Oral l-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease.Atherosclerosis. 1997; 129: 261-269
- Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase.Circ. Res. 2000; 86: E36-E41
- Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis.Circulation. 1998; 97 (See comments): 2494-2498
- Long-term inhibition of NO synthesis promotes atherosclerosis in hypercholesterolaemic rabbit thoracic aorta: PGH2 does not contribute to impaired endothelium-dependent relaxation.Arterioscler. Thromb. Vasc. Biol. 1994; 14: 746-752
- Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolaemic rabbits.Arterioscler. Thromb. Vasc. Biol. 1994; 14: 753-759
- Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease.Circulation. 1997; 96: 3378-3383
- Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.J. Biol. Chem. 1993; 268: 17478-17488
- A common variant of the endothelial nitric oxide synthase Glu298Asp is a major risk factor for coronary artery disease in the UK.Circulation. 1999; 100: 1515-1520
- Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.J. Am. Coll. Cardiol. 1998; 31: 1506-1510
- Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction.Hypertension. 1998; 32: 521-526
- Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proetiens with aspartate vs. glutamate at position 298.Proc. Natl. Acad. Sci. USA. 2000; 97: 2832-2835
- G894T polymorphism in eNOS is associated with enhanced vascular response to phenylephrine.Circulation. 1999; 99 (Abstract): 3096-3098
- Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population.Am. J. Cardiol. 1998; 81: 83-86
- A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene.Nat. Med. 1996; 2: 41-45
- Polymorphisms of the endothelial nitric oxide synthase gene – no consistent association with myocardial infarction in the ECTIM study.Eur. J. Clin. Invest. 1999; 29: 284-290
- Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases.Nephrol. Dial. Transplant. 1999; 14: 2898-2902
- Effect of a polymorphism of endothelial nitric oxide synthase gene in Japanese patients with IgA nephropathy.Clin. Nephrol. 1999; 52: 203-209
- T-786-C Mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm.Circulation. 1999; 99: 2864-2870
Article info
Publication history
Accepted:
October 13,
2000
Received in revised form:
September 27,
2000
Received:
September 15,
2000
Identification
Copyright
© 2001 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
