Abstract
Previous studies on the effect of apoprotein E (APOE) polymorphism on the response
of serum lipids to diet showed inconsistent results. We therefore studied the effect
of apoprotein E polymorphism on responses of serum cholesterol and lipoproteins to
various dietary treatments. We combined data on responses of serum cholesterol and
lipoproteins to saturated fat, to trans-fat, to dietary cholesterol, and to the coffee diterpene cafestol with newly obtained
data on the apoprotein E polymorphism in 395 mostly normolipidemic subjects. The responses
of low-density lipoprotein (LDL-) cholesterol to saturated fat were 0.08 mmol/l larger
in subjects with the APOE3/4 or E4/4 genotype than in those with the APOE3/3 genotype
(95% confidence interval: −0.01–0.18 mmol/l). In contrast, responses of LDL-cholesterol
to cafestol were 0.11 mmol/l smaller in subjects with the APOE3/4 or E4/4 genotype
than in those with the APOE3/3 genotype (95% confidence interval: −0.29–0.07 mmol/l).
Responses to dietary cholesterol and trans-fat did not differ between subjects with the various APOE genotypes. In conclusion,
the APOE genotype may affect the response of serum cholesterol to dietary saturated
fat and cafestol in opposite directions. However, the effects are small. Therefore,
knowledge of the APOE genotype by itself may be of little use in the identification
of subjects who respond to diet.
Keywords
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Article info
Publication history
Accepted:
October 12,
2000
Received in revised form:
September 18,
2000
Received:
May 9,
2000
Identification
Copyright
© 2001 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
