Abstract
The dyslipidemic state of visceral obesity is characterized by increased plasma triglyceride
levels, low high-density lipoprotein-cholesterol concentration and alterations in
low-density lipoprotein (LDL) composition and concentration. A functional, non-coding
microsomal triglyceride transfer protein (MTP) −493G/T polymorphism of the microsomal
triglyceride transfer protein gene has been related to variations in LDL-cholesterol
levels. To study the effect of the MTP −493G/T polymorphism on lipoprotein levels
in visceral obesity and hyperinsulinemia, a total of 227 men were assigned into two
groups on the basis of their MTP −493G/T polymorphism, including 121 GG homozygotes
and 105 carriers of the T allele (92 GT and 13 TT). The two genotypic groups did not
differ for their physiological characteristics nor for lipoprotein–lipid profiles,
before and after adjustment for age. However, GG homozygotes were characterized by
higher fasting insulin levels than carriers of the T allele (P<0.05). When the two genotypic groups were further divided on the basis of their visceral
adipose tissue (AT) accumulation, assessed by computed tomography, we observed that
T allele carriers with low levels of visceral AT (<130 cm2) had decreased plasma total cholesterol and LDL-apolipoprotein B (LDL-apoB) levels
compared to viscerally obese men (P=0.035 and P=0.0001, respectively). Among GG homozygotes, no significant difference were observed.
Although not significant, T allele carriers characterized by visceral obesity tended
to have smaller, denser LDL particles than T allele carriers characterized by a low
accumulation of visceral AT. When subjects were divided on the basis of their fasting
insulin levels, it appears that hyperinsulinemic men were characterized by a deteriorated
lipoprotein–lipid profile when they were carriers of the T allele compared to normoinsulinemic
men. In summary, visceral obesity and hyperinsulinemia modulate the impact of the
MTP −493G/T polymorphism on plasma total cholesterol and LDL-apoB levels, as well
as on LDL peak particle diameter.
Keywords
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Article Info
Publication History
Accepted:
May 21,
2001
Received:
September 22,
2000
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
