Abstract
Radial arteries, used in revascularisation surgery, are prone to spasm. We have examined
the ability of nitrovasodilators, calcium channel blockers, and KATP channel openers to cause vasodilation, and to attenuate contractions due to depolarisation
and receptor activation in radial and mammary arteries used in coronary artery bypass
graft surgery. Two to three millimetre rings of artery obtained from patients at surgery
were studied in organ baths in vitro. Constriction to KC1 and phenylephrine was examined
before and again after treatment of the rings with drug or vehicle. Calcium channel
blockers were the only compounds to inhibit contractions to both KC1 and phenylephrine.
Sodium nitroprusside attenuated constriction to phenylephrine but not KC1 in both
vessels. KATP channel openers similarly attenuated constriction to phenylephrine in radial arteries
but were much less effective in mammary arteries. These studies support the continued
use of calcium blockers after revascularisation with radial artery but suggest that
other classes of drug may be as effective at minimising spasm due to receptor mediated
constriction.
Keywords
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Article info
Publication history
Accepted:
June 27,
2001
Received in revised form:
June 20,
2001
Received:
February 19,
2001
Identification
Copyright
© 2002 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
