Advertisement

Red wine, resveratrol, Chlamydia pneumoniae and the French connection

  • Christopher Schriever
    Affiliations
    Microbiology Research Laboratory, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Search for articles by this author
  • Susan L. Pendland
    Affiliations
    Microbiology Research Laboratory, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Search for articles by this author
  • Gail B. Mahady
    Correspondence
    Corresponding author. Tel.: +1-312-996-1669; fax: +1-312-996-1797.
    Affiliations
    Department of Pharmacy Practice, Program for Collaborative Research in the Pharmaceutical Sciences, UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Search for articles by this author
      Chlamydia pneumoniae is an intracellular gram-negative pathogen, responsible for 5–30% of acute respiratory tract infections worldwide [
      • Halm E.A.
      • Teirstein A.S.
      Management of community-acquired pneumonia.
      ,
      • Grayston J.T.
      Background and current knowledge of Chlamydia pneumoniae and atherschlerosis.
      ]. However, while infection begins in the respiratory tract, the bacterium is disseminated systemically in the blood stream within alveolar macrophages, and can lead to the development of chronic infection [
      • Grayston J.T.
      Background and current knowledge of Chlamydia pneumoniae and atherschlerosis.
      ]. Recent investigations have suggested that chronic C. pneumoniae infection may be a causative factor in the development of atherosclerosis and coronary heart disease (CHD) [
      • Grayston J.T.
      Background and current knowledge of Chlamydia pneumoniae and atherschlerosis.
      ,
      • Noll G.
      Pathogenesis of atherosclerosis: a possible relation to infection.
      ]. This association has been demonstrated in seroepidemiological investigations, as well as by immunocytochemical staining, polymerase chain reaction (PCR) and electron microscopy of atherosclerotic plaque [
      • Noll G.
      Pathogenesis of atherosclerosis: a possible relation to infection.
      ]. Thus, there is a growing body of evidence that C. pneumoniae is associated with the development or progression of atherosclerotic plaque and CHD [
      • Grayston J.T.
      Background and current knowledge of Chlamydia pneumoniae and atherschlerosis.
      ,
      • Noll G.
      Pathogenesis of atherosclerosis: a possible relation to infection.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Halm E.A.
        • Teirstein A.S.
        Management of community-acquired pneumonia.
        N. Eng. J. Med. 2002; 347: 2039-2045
        • Grayston J.T.
        Background and current knowledge of Chlamydia pneumoniae and atherschlerosis.
        J Infect. Dis. 2000; 181: S402-S410
        • Noll G.
        Pathogenesis of atherosclerosis: a possible relation to infection.
        Atherosclerosis. 1998; 140: S3-S9
        • Renaud S.
        • de Lorgeril M.
        The French paradox: dietary factors and cigarette smoking-related health risks.
        Ann. NY Acad. Sci. 1993; 686: 299-309
        • Kopp P.
        Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the French Paradox?.
        Eur J. Endocrinol. 1998; 138: 619-620
        • Mahady G.B.
        • Pendland S.L.
        Resveratrol inhibits the growth of Helicobacter pylori in vitro.
        Am. J. Gastroenterol. 2001; 96: 3454-3455
      1. National Committee for Clinical and Laboratory Standards (NCCLS). Performance standards for antimicrobial susceptibility testing; Twelfth Informational Supplement, January 2002.

        • Hammerschlag M.R.
        • Qumei K.K.
        • Roblin P.M.
        In vitro activities of azithromycon, clarithromycin, l-ofloxacin, and other antibiotics against Chlamydia pneumoniae.
        Antimicrob. Agents Chemother. 1992; 7: 1573-1574
        • Suchland R.J.
        • Geisler W.M.
        • Stamm W.E.
        Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp.
        Antimicrob. Agents Chemother. 2003; 47: 636-642
        • Mosmann T.
        Rapid colorimetric assay for cellular growth and survival: application to proliferration and cytotoxicity assays.
        J. Immunol. Methods. 1983; 65: 55-63