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Adventitial heat shock protein 60 in human coronary atherosclerosis

      Two recent papers in Atherosclerosis [
      • Lamb D.J.
      • El-Sankary W.
      • Ferns G.A.A.
      Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation.
      ,
      • George J.
      • Greenberg S.
      • Barshack I.
      • Goldberg I.
      • Keren G.
      • Roth A.
      Immunity to heat shock protein 65—an additional determinant in intimal thickening.
      ] updated the accumulating evidence for the atherogenic potential of heat shock proteins (HSP) in the molecular mimicry hypothesis of atherosclerosis [
      • Lamb D.J.
      • El-Sankary W.
      • Ferns G.A.A.
      Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation.
      ,
      • George J.
      • Greenberg S.
      • Barshack I.
      • Goldberg I.
      • Keren G.
      • Roth A.
      Immunity to heat shock protein 65—an additional determinant in intimal thickening.
      ,
      • George J.
      • Afek A.
      • Gilburd B.
      • Harats D.
      • Shoenfeld Y.
      Auto-immunity in atherosclerosis: lessons from experimental models.
      ,
      • Perschinka H.
      • Mayr M.
      • Millonig G.
      • Mayerl C.
      • Van Der Zee R.
      • Morrison S.G.
      • et al.
      Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
      ]. In their review, Lamb et al. [
      • Lamb D.J.
      • El-Sankary W.
      • Ferns G.A.A.
      Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation.
      ] also emphasized that “immunisation with HSP and HSP-containing vaccines exacerbates atherogenesis in experimental models.”
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      References

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        • El-Sankary W.
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        Molecular mimicry in atherosclerosis: a role for heat shock proteins in immunisation.
        Atherosclerosis. 2003; 167: 177-185
        • George J.
        • Greenberg S.
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        Immunity to heat shock protein 65—an additional determinant in intimal thickening.
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        • et al.
        Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
        Arterioscler. Thromb. Vasc. Biol. 2003; 23: 1060-1065
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      2. Ghenev PI. Atherosclerotic intimal, medial and adventitial changes in human aorta, coronary and cerebral arteries. Comparative morphological study. Ph.D Thesis, Medical University, Varna, Bulgaria, 2002.

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