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Influenza—a trigger for acute myocardial infarction

      The relationship between inflammation and the progression of atherosclerosis has been widely discussed within the last decade [
      • Ridker P.M.
      • Cushman M.
      • Stampfer M.J.
      • Tracy R.P.
      • Hennekens C.H.
      Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
      ]. Effects of infection can range from early onset of atherogenesis to the possible triggering of acute events. The influence of chronic infectious diseases on atherosclerosis progression has been thoroughly investigated. But the impact of an acute infection on the incidence of complications of atherosclerosis is at least of the same importance. The possible coincidence of influenza and an increase in myocardial infarction (MI) incidence has been studied, though in most studies only mortality data were used [
      • Tillet H.E.
      • Smith J.W.G.
      • Gooch C.D.
      Excess death attributable to influenza in England and Wales: age at death and certified cause.
      ]. We investigated the relationship between influenza epidemics and the incidence of acute myocardial infarction.
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      References

        • Ridker P.M.
        • Cushman M.
        • Stampfer M.J.
        • Tracy R.P.
        • Hennekens C.H.
        Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men.
        N. Engl. J. Med. 1997; 336: 973-979
        • Tillet H.E.
        • Smith J.W.G.
        • Gooch C.D.
        Excess death attributable to influenza in England and Wales: age at death and certified cause.
        Int. J. Epidemiol. 1983; 12: 344-352
        • Gurfinkel E.P.
        • de la Fuente R.L.
        • Mendiz O.
        • Mautner B.
        Influenza vaccine pilot study in acute coronary syndromes and planned percutaneous coronary interventions.
        Circulation. 2002; 105: 2143-2147