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Relationship of post-heparin hepatic and lipoprotein lipases to high density lipoprotein modulation in obese children

      Hepatic lipase (HL) activity was a strong contributor to high-density lipoprotein (HDL) heterogeneity in normal physiological states [
      • Carr M.C.
      • Ayyobi A.F.
      • Murdoch S.J.
      • Deeb J.D.
      • Brunzell J.D.
      Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women.
      ]. It is well known that obesity is sometimes associated with a decreased level of HDL cholesterol and an increased level of HL activity. Therefore, apolipoproteins A-I (apo A-I) and A-II (apo A-II), the major components of HDL, may also contribute to structural and functional heterogeneity, because they have different roles in reverse cholesterol transport [
      • Tailleux A.
      • Duriez P.
      • Fruchart J.C.
      • Clavey V.
      Apolipoprotein A-II, HDL metabolism and atherosclerosis.
      ].
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