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Hyperhomocysteinemia due to Helicobacter pylori?

      Recent reports in the literature, as summarized by Lacy and Rosemore [
      • Lacy B.E.
      • Rosemore J.
      Helicobacter pylori: ulcers and more. Beginning of an era.
      ], suggest an association of Helicobacter pylori (H. pylori) with many human chronic diseases. Linking H. pylori with coronary heart disease (CHD), however, has received a greater attention than other diseases in recent years. Although many research findings support the notion that this organism could be an etiological factor for CHD, convincing mechanisms of this action are yet to be established. Markle [
      • Markle P.
      Coronary artery disease associated with helicobacter pylori infection is at least partially due to inadequate folate status.
      ] earlier proposed one such mechanism, based on the fact that H. pylori is capable of inducing malabsorption of folate and Vitamin B12, leading to hyperhomocysteinemia, which is considered to be one of the risk factors for CHD. Since we had some ongoing projects estimating plasma total homocysteine (tHCY) along with several associated micronutrients, particularly plasma folate and Vitamin B12, in humans, we were tempted to examine if H. pylori is indeed involved in the production of hyperhomocysteinemia in this population.
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