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The role of the A54T polymorphism of the intestinal fatty acid binding protein for lipid levels, insulin sensitivity and carotid atherosclerosis

Results of the Salzburg Atherosclerosis Prevention Program in subjects at high individual risk (SAPHIR)
      Metabolic syndrome, a common phenotype characterized by dyslipidemia, obesity, hypertension, and insulin resistance [
      • Haffner S.M.
      • Valdez R.A.
      • Hazuda H.P.
      • Mitchell B.D.
      • Morales P.A.
      • Stern M.P.
      Prospective analysis of the insulin-resistance syndrome (syndrome X).
      ], is a strong risk factor for coronary heart disease. The etiology of this syndrome is not fully understood, but includes genetic as well as environmental factors [
      • Mitchell B.D.
      • Kammerer C.M.
      • Mahaney M.C.
      • Blangero J.
      • Comuzzie A.G.
      • Atwood L.D.
      • et al.
      Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures.
      ].
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