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Serum butyrylcholinesterase activity in hyperlipidaemia

  • János Kálmán
    Correspondence
    Corresponding author. Tel.: +36-625-45360; fax: +36-625-45973.
    Affiliations
    Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • Anna Juhász
    Affiliations
    Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • Zoltán Rakonczay
    Affiliations
    Alzheimer’s Disease Research Centre, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • György Ábrahám
    Affiliations
    Ist Department of Internal Medicine, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • Krisztina Boda
    Affiliations
    Medical Informatics, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • Tibor Farkas
    Affiliations
    Department of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, H-6701 Szeged, Hungary
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  • Botond Penke
    Affiliations
    Medical Chemistry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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  • Zoltán Janka
    Affiliations
    Department of Psychiatry, Albert Szent-Györgyi Center for Medical and Pharmaceutical Sciences, Faculty of Medicine, University of Szeged, Semmelweis u.6., H-6725 Szeged, Hungary
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      Butyrylcholinesterase (BChE), also known as “pseudo” or “non”-neuronal cholinesterase, is widely distributed in different tissues within the human body, such as the serum, haemopoietic cells, liver, lung, heart, glial cells, astrocytes and cholinergic synapses within the central nervous system [

      Silver A. The Biology of Cholinesterases. North-Holland: Amsterdam; 1974.

      ]. BChE has been reported to be predominantly present in the serum and its activity is positively correlated with serum triglyceride, cholesterol apolipoprotein B, levels and diabetes mellitus [
      • Abbott C.A.
      • Mackness M.I.
      • Kumar S.
      • Olukoga A.O.
      • Gordon C.
      • Arrol S.
      • et al.
      Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus.
      ,
      • Alcantara V.M.
      • Chautard-Freire-Maia E.A.
      • Scartezini M.
      • Cerci M.S.
      • Braun-Prado K.
      • Picheth G.
      Butyrylcholinesterase activity and risk factors for coronary artery disease.
      ]. The inheritance of the apolipoprotein E4 (APOE4) allele has been shown to increase the plasma cholesterol level, but no information is yet available concerning the association of the APOE genotype and hyperlipidaemia and the activities of two serum enzymes, BChE and acetylcholinesterase (AChE). The objective of the present study, therefore was to examine the relationship between the most frequent lipid abnormalities observed in Alzheimer’s disease (AD) and vascular dementia (VD) and the activities of BChE and AChE in human serum.
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