Abstract
Inflammation has been postulated to be a major contributor to restenosis after angioplasty.
We examined the correlation between inflammatory and coagulatory reactions and the
occurrence of restenosis, and how treatment with statins influences this correlation.
A total of 243 patients with stable angina who were scheduled for a percutaneous coronary
intervention (PCI) and follow-up coronary angiography were enrolled in the study.
Eighty-one of these patients were treated with statins for at least 1 month before
their PCI and throughout the study period. Blood was withdrawn on the day of the PCI
and on the day of the follow-up catheterization. Patients with the highest hs-CRP
at the time of the initial PCI maintained elevated hs-CRP levels over time and showed
significantly higher rates of restenosis or TLR after 6±1 months than subjects with
low initial hs-CRP. Statin treatment abolished this difference. Fibrinogen levels
were also increased in subjects with high initial hs-CRP, both at the time of the
initial PCI and at follow-up. In an univariate analysis, both initial and follow-up
levels of hs-CRP and fibrinogen correlated with restenosis. However, both the initial
and follow-up levels of hs-CRP only were independent predictors of increased restenosis
in a multivariate analysis, except in the statin-treated subgroup. In conclusions,
the persistent increase in CRP is a risk factor for restenosis in patients with stable
angina who have not been treated with statins.
Keywords
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Article info
Publication history
Accepted:
December 19,
2003
Received:
June 16,
2003
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
