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Increased serum levels of soluble ICAM-1 and IL-6 reflect endothelial dysfunction in statin-treated patients with hypercholesterolaemia

      We have recently published results of a clinical trial examining the long term effects of statin therapy on endothelial-dependent brachial artery flow-mediated dilatation (FMD), sICAM-1 and IL-6 serum levels in patients with hypercholesterolaemia [
      • Nawawi H
      • Osman N.S
      • Annuar R
      • Khalid B.A
      • Yusoff K
      Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin.
      ].
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      References

        • Nawawi H
        • Osman N.S
        • Annuar R
        • Khalid B.A
        • Yusoff K
        Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin.
        Atherosclerosis. 2003; 169: 283-291
        • Krieglstein C.F
        • Granger D.N
        Adhesion molecules and their role in vascular disease.
        Am. J. Hypertens. 2001; 14: 44S-54S
        • Leuwenberg J.F
        • Smeets E.F
        • Neefjes J.J
        • et al.
        E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.
        Immunology. 1992; 77: 543-549
        • Witte D.R
        • Broekmans W.M.R
        • Kardinaal A.F.M
        • et al.
        Soluble intercellular adhesion molecule 1 and flow mediated dilatation are related to the estimated risk of coronary heart disease independently from each other.
        Atherosclerosis. 2003; 170: 147-153
        • Rezaie-Majd A
        • Prager G.W
        • Bucek R.A
        • et al.
        Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolaemic patients.
        Arterioscler. Thromb. Vasc. Biol. 2003; 23: 397-403
        • Mueck A.O
        • Seeger H
        • Wallwiener D
        Further evidence for direct vascular actions of statins: effect on endothelial nitric oxide synthase and adhesion molecules.
        Exp. Clin. Endocrinol. Diabetes. 2001; 109: 181-183
        • John S
        • Jacobi J
        • Delles C
        • et al.
        Plasma soluble adhesion molecules and endothelium-dependent vasodilatation in early human atherosclerosis.
        Clin. Sci. (Lond.). 2000; 98: 521-529
        • Stad R.K
        • Buurman W.A
        Current views on structure and function of endothelial adhesion molecules.
        Cell Adhes. Commun. 1994; 2: 261-268
        • Hulthe J
        • Wikstrand J
        • Mattsson-Hulten L
        • Fagerberg B
        Circulating ICAM-1 is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year old men: the Atherosclerosis and Insulin Resistance (AIR) study.
        Clin. Sci. (Lond). 2002; 103: 123-129
        • Jacobson S.H
        • Egberg N
        • Hylander B
        • Lundahl J
        Correlation between soluble markers of endothelial dysfunction in patients with renal failure.
        Am. J. Nephrol. 2002; 22: 42-47