Abstract
Background:
Insulin resistance (IR) is associated with a significant increase in the risk of coronary
artery disease (CAD). The serum apolipoprotein B and Apo A1/Apo B ratio are important
markers of CAD. The aim of this study was to assess the association of the serum Apo
B and Apo A1/Apo B ratio, with insulin resistance in apparently healthy normoglycemic
Koreans.
Methods:
From the individuals that participated in medical screening at the health promotion
center of Kangbuk Samsung Hospital, between January and December 2002, a total of
7427 participants (4356 men, 3071 women) were enrolled in this study. All participants
had no personal histories of diabetes, with normal fasting glucose levels. The clinical
characteristics and biochemical parameters of the subjects were assessed.
Results:
The Apo B, total cholesterol/high-density lipoprotein-cholesterol (HDL-C) and low-density
lipoprotein-cholesterol (LDL-C)/high-density lipoprotein-cholesterol showed positive
correlations with metabolic syndrome and insulin resistance (p < 0.001). The Apo A1, Apo A1/Apo B, LDL/Apo B and HDL/Apo A1 showed negative correlations
with metabolic syndrome and insulin resistance (p < 0.001).
Conclusion:
These data suggest that insulin resistance may be associated with the serum Apo B
and Apo A1/Apo B ratio in non-diabetic, normoglycemic subjects. Thus, further study
may be needed to determine whether medical intervention is inevitable or not in these
type of subjects.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to AtherosclerosisAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Microalbuminuria is associated with insulin resistance in non-diabetic subjects: the Insulin Resistance Atherosclerosis Study.Diabetes. 1998; 47: 793-800
- Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.Diab Care. 1991; 14: 173-194
- The deadly guartet: upper-body obesity, glucose intolerance, hyper-triglyceridemia, and hypertension.Arch Intern Med. 1989; 149: 1514-1520
- Development of the multiple metabolic syndrome in the ARIC Cohort: Joint contribution of insulin, BMI, and WHR.AEP. 1997; 7: 407-416
- Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia and coronary artery disease.Am Heart J. 1991; 121: 1283
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285:2486–97.
- Approach to lipoprotein management in 2001 National Cholesterol Guidelines.Am J Cardiol. 2002; 17: 11i-21i
- Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study.Circulation. 1997; 95: 69-75
- Nonfasting apolipoprotein B and triglyceride levels as a useful predictor of coronary heart disease risk in middle-aged UK men.Arterioscler Thromb Vasc Biol. 2002; 22: 1918-1923
- Coronary artery disease is associated with the ratio of apolipoprotein A-I/B and serum concentration of apolipoprotein B, but not with paraoxonase enzyme activity in Iranian subjects.Atherosclerosis. 2002; 162: 381-389
- Non-HDL-cholesterol and apolipoprotein B in the dyslipidemic classification of type 2 diabetic patients.Diab Care. 2003; 26: 2048-2051
- High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study.Lancet. 2001; 358: 2026-2033
- Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment.Lancet. 2003; 361: 777-780
- Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance.N Engl J Med. 1989; 320: 702-706
- Insulin, proinsulin and insulin resistance status in relation to lipid profiles among school children in Taiwan—The Taipei Children Heart Study.Clin Biochem. 2003; 36: 367-372
- Hyperinsulinemia as an independent risk factor for ischemic heart disease.N Engl J Med. 1996; 334: 952-957
- Plasma very low-density lipoproteins contain a single molecule of apolipoprotein B.J Lipid Res. 1988; 29: 1461-1473
- Hypertriglyceridemic hyperapoB: the unappreciated atherogenic dyslipoproteinemia in type 2 diabetes mellitus.Ann Intern Med. 2001; 135: 447-459
- Apolipoprotein A-1 and B levels and the risk of ischemic heart disease during a 5-year follow-up of men in the Quebec Cardiovascular Study.Circulation. 1996; 94: 273-278
- Total cholesterol/HDL-cholesterol ratio versus LDL-cholesterol/HDL-cholesterol ratio as indices of ischemic heart disease risk in men: The Quebec Cardiovascular Study.Arch Intern Med. 2001; 161: 2685-2692
- Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model.J Biol Chem. 2000; 275: 8416-8425
- Hepatic very low-density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance.J Biol Chem. 2002; 277: 793-803
Article info
Publication history
Accepted:
November 19,
2004
Received in revised form:
October 12,
2004
Received:
April 29,
2004
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
