Abstract
Objective
Circulating oxidized low-density lipoprotein (LDL) has been shown to be a useful marker
for identifying patients with coronary heart disease (CHD) and persons at high cardiovascular
risk. The effect of cholesterol-lowering therapy on plasma level of oxidized LDL is
not clear.
Methods and results
We investigated effects of cholesterol lowering by therapeutic intervention (2 years)
with atorvastatin (80 mg daily) and simvastatin (40 mg daily) on circulating oxidized LDL (absolute level and in proportion to plasma
apolipoprotein B) in relation to atherosclerosis progression (carotid intima-media
thickness, carotid IMT) and to inflammation (high-sensitivity C-reactive protein,
hsCRP) in 115 stable patients with heterozygous familial hypercholesterolemia (FH).
Atorvastatin and simvastatin reduced plasma-oxidized LDL (−43 and −35%, respectively)
in proportion to the decrease in plasma apolipoprotein B. Neither absolute nor relative
level of oxidized LDL correlated with carotid IMT or hsCRP at baseline. Also changes
in levels of circulating oxidized LDL were not related to changes in carotid IMT and
hsCRP.
Conclusions
In familial hypercholesterolemia-oxidized LDL carried in plasma is strongly associated
with apolipoprotein B but not with inflammation nor with carotid IMT, and statin treatment
does not reduce oxidized LDL relative to apolipoprotein B.
Keywords
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Article info
Publication history
Published online: July 11, 2005
Accepted:
June 2,
2005
Received in revised form:
May 25,
2005
Received:
February 7,
2005
Identification
Copyright
© 2005 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
