Abstract
Although previous epidemiologic studies have suggested an association between the
onset of myocardial infarction (MI) and some genetic variations, the impact of these
variants on recurrent cardiovascular events after MI has not been fully elucidated.
We genotyped 87 polymorphisms of 73 atherosclerosis-related genes in consecutive acute
MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared
the incidence of death and major adverse cardiac events (MACE) among the polymorphisms
of each gene. After initial screening in 507 patients, we selected nine polymorphisms
for screening in all 1586 patients. Multivariate Cox regression analysis revealed
that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were
independently associated with an increased risk of death (hazard ratio [HR]: 2.46;
95% CI: 1.24–4.86). In conclusion, a 252G allele of LTA is associated with an increased
risk of death after AMI and may be a useful genetic predictor.
Keywords
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Article Info
Publication History
Published online: July 29, 2005
Accepted:
June 20,
2005
Received in revised form:
April 26,
2005
Received:
November 9,
2004
Identification
Copyright
© 2005 Published by Elsevier Inc.
