Abstract
Although previous epidemiologic studies have suggested an association between the
onset of myocardial infarction (MI) and some genetic variations, the impact of these
variants on recurrent cardiovascular events after MI has not been fully elucidated.
We genotyped 87 polymorphisms of 73 atherosclerosis-related genes in consecutive acute
MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared
the incidence of death and major adverse cardiac events (MACE) among the polymorphisms
of each gene. After initial screening in 507 patients, we selected nine polymorphisms
for screening in all 1586 patients. Multivariate Cox regression analysis revealed
that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were
independently associated with an increased risk of death (hazard ratio [HR]: 2.46;
95% CI: 1.24–4.86). In conclusion, a 252G allele of LTA is associated with an increased
risk of death after AMI and may be a useful genetic predictor.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to AtherosclerosisAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction.Nat Genet. 2002; 32: 650-654
- Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.Nature. 2004; 429: 72-75
- Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.N Engl J Med. 2002; 347: 1916-1923
- Genetic markers: progress and potential for cardiovascular disease.Circulation. 2004; 109: 47-58
- Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population.Hum Genet. 2000; 106: 288-292
- Impact of high-sensitivity C-reactive protein on predicting long-term mortality of acute myocardial infarction.Am J Cardiol. 2003; 91: 931-935
- The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIIIB: European Atherosclerosis Research Study (EARS) II.Arterioscler Thromb Vasc Biol. 1999; 19: 303-308
- Variation in the interleukin-4 receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.Am J Hum Genet. 2000; 66: 517-526
- Interleukin-18 promoter polymorphisms in type 1 diabetes.Diabetes. 2002; 51: 3347-3349
- Linkage of inflammatory bowel disease to human chromosome 6p.Am J Hum Genet. 1999; 65: 1647-1655
- Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.Proc Natl Acad Sci USA. 1995; 92: 1851-1855
- Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms.J Biol Chem. 2000; 275: 28873-28881
- Association of the C-509-->T polymorphism, alone of in combination with the T869-->C polymorphism, of the transforming growth factor-beta 1 gene with bone mineral density and genetic susceptibility to osteoporosis in Japanese women.J Mol Med. 2001; 79: 149-156
- Characterization of the human thrombopoietin gene promoter. A possible role of an Ets transcription factor, E4TF1/GABP.J Biol Chem. 1997; 272: 11361-11368
- Variation at the von Willebrand factor (vWF) gene locus is associated with plasma vWF:Ag levels: identification of three novel single nucleotide polymorphisms in the vWF gene promoter.Blood. 1999; 93: 4277-4283
- Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure.Circulation. 1995; 92: 1479-1486
- Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart.Circulation. 1996; 93: 704-711
- Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes.Immunology. 1990; 71: 364-367
- Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development.J Immunol. 1998; 161: 6853-6860
- Loss of lymphotoxin-alpha but not tumor necrosis factor-alpha reduces atherosclerosis in mice.J Biol Chem. 2002; 277: 12364-12368
- LTA 252G allele containing haplotype block is associated with high serum C-reactive protein levels.Atherosclerosis. 2004; 176: 91-94
- Association analysis between polymorphisms of the lymphotoxin-alpha gene and myocardial infarction in a Japanese population.Atherosclerosis. 2004; 172: 197-198
- A trio family study showing association of the lymphotoxin-alpha N26 (804A) allele with coronary artery disease.Eur J Hum Genet. 2004; 12: 770-774
- Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men.Atherosclerosis. 2001; 154: 691-697
Article info
Publication history
Published online: July 29, 2005
Accepted:
June 20,
2005
Received in revised form:
April 26,
2005
Received:
November 9,
2004
Identification
Copyright
© 2005 Published by Elsevier Inc.
