Abstract
Elevation in plasma triglycerides (TG) has been widely accepted as a coronary artery
disease (CAD) risk predictor. Recently, a new apolipoprotein playing an important
role in TG metabolism named apolipoprotein AV (apoAV) was discovered, which is encoded
by the APOA5 gene. Several single nucleotide polymorphisms (SNPs) of APOA5 associated with increased TG concentrations have been identified. We here report
that a recently identified genetic variant, c.553G > T in the APOA5 gene which causes a substitution of a cysteine for a glycine residue at amino acid
residue 185(G185C) is also associated with increased TG levels. To investigate the
association between this genetic variation and the risk of CAD, a case-control study
comprising 232 patients with CAD and 302 controls from the same area of China was
performed. The minor allele frequencies of c.553G > T for the CAD and control groups were 7.76 and 3.97%, respectively (P = 0.008). In both the CAD and control groups, the T allele carriers had higher serum
TG levels than homozygous carriers of the major G allele (CAD group: 2.67 ± 1.48 mmol/l versus 1.95 ± 1.02 mmol/l, P = 0.021; controls: 2.31 ± 1.20 mmol/l versus 1.68 ± 0.95 mmol/l, P = 0.002). After adjustment for age, gender, body mass index, smoking status, glucose
and presence of hypertension, the odds ratio (OR) for CAD in the T allele carriers
was 2.089 (95% CI = 1.140–3.830, P = 0.017), in comparison to the individuals without the T allele. These results suggest
that the APOA5 c.553G > T polymorphism is an important predictor for hypertriglyceridemia and CAD.
Keywords
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Article info
Publication history
Published online: July 27, 2005
Accepted:
June 21,
2005
Received in revised form:
June 6,
2005
Received:
February 2,
2005
Identification
Copyright
© 2005 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
