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The FORT test—A novel oxidative stress marker or a well-known measure of ceruloplasmin oxidase activity?

      We read with interest the article by Abramson et al. suggesting that oxidative stress, as measured by the free oxygen radical test (FORT), may be a determinant of CRP levels and promote pro-atherosclerotic inflammatory processes at the earliest stages of CHD development [
      • Abramson J.L.
      • Hooper W.C.
      • Jones D.P.
      • et al.
      Association between novel oxidative stres markers and C-reactive protein among adults without clinical coronary heart disease.
      ]. In this study, the correlation between FORT results and acute phase reactant hsCRP was investigated and a highly significant positive correlation was found.
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      References

        • Abramson J.L.
        • Hooper W.C.
        • Jones D.P.
        • et al.
        Association between novel oxidative stres markers and C-reactive protein among adults without clinical coronary heart disease.
        Atherosclerosis. 2005; 178: 115-121
        • Erel O.
        A new automated colorimetric method for measuring total oxidant status.
        Clin Biochem. 2005; 38 ([Epub October 7, 2005]): 1103-1111
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        • Nadlinger K.
        • Adelwohrer N.
        • et al.
        Oxidative stress: potential of distinct peroxide determination systems.
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        Hydrogen peroxide in the human body.
        FEBS Lett. 2000; 486: 10-13

      Linked Article

      • The FORT test: Reply to Dr Harma and colleagues
        AtherosclerosisVol. 187Issue 2
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          In their letter to the Editor, Dr. M.I. Harma and colleagues claim that there are a number of problems associated with the d-ROMs test and related tests, such as the FORT. For example, the letter claims that a problem with the d-ROMs test is that it fails to show a linear correlation with H2O2, suggesting that the d-ROMs test is a poor measure of oxidative stress. Whether or not this problem truly exists with the d-ROMs test is unclear, because the article cited by Harma and colleagues fails to show any data on the analyses they conducted between the d-ROMs test and H2O2 [1].  
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