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White blood cell count is a marker of wave reflections and arterial stiffness in healthy individuals

      Increased white blood cell count (WBC-C), a marker of chronic, subclinical, low-grade inflammation has been associated with cardiovascular events, incidence of hypertension and subclinical atherosclerosis [
      • Kannel W.B.
      • Anderson K.
      • Wilson P.W.
      White blood cell count and cardiovascular disease. Insights from the Framingham Study.
      ,
      • Sabatine M.S.
      • Morrow D.A.
      • Cannon C.P.
      • et al.
      Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy.
      ,
      • Shankar A.
      • Klein B.E.
      • Klein R.
      Relationship between white blood cell count and incident hypertension.
      ]. Augmentation index (AIx) is a composite measure of arterial stiffness and wave reflections, which are strong determinants of cardiovascular performance and independent predictors of the corresponding risk [
      • Weber T.
      • Auer J.
      • O’Rourke M.F.
      • et al.
      Arterial stiffness, wave reflections, and the risk of coronary artery disease.
      ,
      • Vlachopoulos C.
      • Aznaouridis K.
      • Stefanadis C.
      Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece.
      ]. In this cross-sectional study we investigated the relationship between AIx and low-grade inflammation expressed by WBC-C in healthy adults.

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