Abstract
Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL) associated enzyme with three
activities which are paraoxonase, arylesterase and dyazoxonase. We aimed to determine
serum (a) paraoxonase and arylesterase activities and, lipid hydroperoxide (LOOH)
levels in patients with iron deficiency anemia (IDA) (b) whether there is an association
between the development of atherosclerosis and paraoxonase/arylesterase activities
in patients with IDA. Twenty-five female with IDA and 22 healthy female as control
were enrolled in the study. Serum basal/salt-stimulated paraoxonase and arylesterase
activities were measured spectrophotometrically. LOOH levels were measured by ferrous
oxidation with xylenol orange assay. Basal/salt-stimulated paraoxonase and arylesterase
activities were significantly lower in patients with IDA than controls (p < 0.001; for all), while LOOH levels were significantly higher (p < 0.001). Our results show that paraoxonase and arylesterase activities, which have
antiatherogenic capability, are decreased in patients with IDA. Reduced paraoxonase
and arylesterase activities may play a role in pathogenesis of atherosclerosis through
increased susceptibility to lipid peroxidation in patients with IDA.
Keywords
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Article info
Publication history
Published online: May 09, 2006
Accepted:
April 4,
2006
Received in revised form:
February 28,
2006
Received:
August 19,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
