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Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals

  • Nobukazu Ishizaka
    Correspondence
    Corresponding author at: Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan. Tel.: +81 3 3815 5411x37156; fax: +81 3 5842 5586.
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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  • Yuko Ishizaka
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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  • Ei-Ichi Toda
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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  • Hideki Hashimoto
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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  • Ryozo Nagai
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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  • Minoru Yamakado
    Affiliations
    Departments of Cardiovascular Medicine (N.I., R.N.) and Health Management and Policy (H.H), University of Tokyo Graduate School of Medicine, and Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital (Y.I., E-I.T., M.Y.), Tokyo, Japan
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      Abstract

      Hyperuricemia is postulated to be a risk factor for atherosclerotic diseases, although whether it is independent of classical atherogenic risk factors is controversial. The automatic computer-assisted measurement of brachial-ankle pulse wave velocity (baPWV) is a valid and reproducible method by which to assess arterial stiffness, a potential surrogate marker of early atherosclerosis. By analyzing cross-sectional data from 982 individuals who underwent health screening, we have investigated whether serum uric acid is associated with high baPWV, which was determined as the highest quartile of baPWV values, in a sex-specific manner. Multivariate analysis showed that the odds ratios (95% CI) of the highest baPWV quartile across the sex-specific quartiles of serum uric acid were 1.0, 2.80 (0.93–8.40), 2.13 (0.74–6.19), and 2.76 (1.01–7.55) in women, and 1.0, 1.10 (0.55–2.20), 1.97 (1.04–3.75), and 2.24 (1.10–4.56) in men after adjusting for age, total and HDL-cholesterol, BMI, systolic blood pressure, triglycerides, fasting glucose and smoking status. The association between uric acid and high baPWV was observed in both subjects with metabolic syndrome and those without. These data suggest that in both genders, serum uric acid level is associated with increased baPWV, a marker of arterial stiffness, and is in part independent of other conventional risk factors for atherosclerosis and metabolic syndrome.

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