Abstract
Evidences suggest that lipoprotein(a) [Lp(a)] is an important risk factor for cardiovascular
disease. However, literature has been controversial in confirming its role as an independent
risk factor for cardiovascular disease. The objective of the present study is to evaluate
the association between serum levels of Lp(a) and ischemic heart disease as well as
other cardiovascular risk factors in a population-based study conducted on a local
cohort of the Brazilian population.
Lp(a) serum levels were measured in 400 individuals selected from a larger sample
of a populational survey carried out in Ouro Preto, a city in the southeast of Brazil.
Lipid profile, fasting blood glucose, anthropometric and clinical parameters were
analyzed.
Lp(a) levels were significantly associated with the presence of ischemic heart disease.
In relation to other cardiovascular risk factors, it was verified that Lp(a) levels
were statistically associated with age, total cholesterol, LDL-cholesterol and percentage
of body fat determined by bioelectric impedance. Lp(a) was also highly associated
with the Framingham risk score (p = 0.003). In a multivariate analysis two significant interactions were revealed; one
involving ischemic heart disease, sex and age and other associating ischemic heart
disease, age and total cholesterol.
In summary, in the present analysis Lp(a) serum levels were correlated with the occurrence
of ischemic heart disease and other cardiovascular risk factors.
Keywords
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Article info
Publication history
Published online: July 16, 2006
Accepted:
April 20,
2006
Received in revised form:
March 15,
2006
Received:
June 20,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
