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An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and postmenopausal women

  • Paul Nestel
    Correspondence
    Corresponding author. Tel.: +61 3 8532 1383; fax: +61 3 8532 1100.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
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  • Author Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    Akihiko Fujii
    Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
    Search for articles by this author
  • Author Footnotes
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.
    Lei Zhang
    Footnotes
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
    Search for articles by this author
  • Author Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.

      Abstract

      Objectives

      Isoflavones reduce arterial stiffness, a predictor of cardiovascular events. Whether metabolites of isoflavones have similar bioactivity is unknown. The effect of supplemental trans-tetrahydrodaidzein (THD) a metabolite of daidzein on pulse wave velocity (PWV), a measure of arterial stiffness was tested in overweight men and postmenopausal women.

      Methods

      25 subjects, 11 postmenopausal women, 14 men (age, 57 [7] years; body mass index, 30.3 [4.7] kg/m2; mean [S.D.]) participated in a double-blind, randomized, cross-over trial of THD versus placebo. Design: 2 weeks run-in followed by either THD 1 g daily or placebo, each intervention 5 weeks. Aorta–femoral artery PWV, blood pressure and plasma lipids were measured after run-in, THD and placebo.

      Results

      PWV was significantly reduced (signifying diminished central arterial stiffness): medians (25th and 75th%), placebo 9.9 m/s (8.7, 11.1), THD 8.8 m/s (7.9, 10.9); RM ANOVA P = 0.023, with Tukey procedure P < 0.05. Systolic blood pressure was significantly reduced: means (S.D.), placebo 125.6 (14.7), THD 121.3 (12.2) mmHg; Tukey P < 0.05. Plasma cholesterol, triglyceride and LDL cholesterol did not differ significantly. Absorption of THD >80% substantially exceeded that of parent isoflavones.

      Conclusion

      A metabolite normally formed after consumption of isoflavones (formononetin, daidezein), taken orally, reduced blood pressure and central arterial stiffness indicating reduced cardiovascular risk.

      Keywords

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