Advertisement
Research Article| Volume 192, ISSUE 1, P184-189, May 2007

An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and postmenopausal women

  • Paul Nestel
    Correspondence
    Corresponding author. Tel.: +61 3 8532 1383; fax: +61 3 8532 1100.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
    Search for articles by this author
  • Author Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    Akihiko Fujii
    Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
    Search for articles by this author
  • Author Footnotes
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.
    Lei Zhang
    Footnotes
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.
    Affiliations
    Baker Heart Research Institute (Wynm Domain), P.O. Box 6492, St. Kilda Rd Central, Melbourne 8008, Australia
    Search for articles by this author
  • Author Footnotes
    1 Present address: Kao Corporation, Tochigi, Japan.
    2 Present address: Cardiovascular Department, 254th Hospital, Tianjin, PR China.
Published:May 28, 2006DOI:https://doi.org/10.1016/j.atherosclerosis.2006.04.033
An isoflavone metabolite reduces arterial stiffness and blood pressure in overweight men and postmenopausal women
Previous ArticleThe association between circulating white blood cell count, triglyceride level and cardiovascular and all-cause mortality: Population-based cohort study
Next ArticleRisk for transient ischemic attacks is mainly determined by intima-media thickness and carotid plaque echogenicity

      Abstract

      Objectives

      Isoflavones reduce arterial stiffness, a predictor of cardiovascular events. Whether metabolites of isoflavones have similar bioactivity is unknown. The effect of supplemental trans-tetrahydrodaidzein (THD) a metabolite of daidzein on pulse wave velocity (PWV), a measure of arterial stiffness was tested in overweight men and postmenopausal women.

      Methods

      25 subjects, 11 postmenopausal women, 14 men (age, 57 [7] years; body mass index, 30.3 [4.7] kg/m2; mean [S.D.]) participated in a double-blind, randomized, cross-over trial of THD versus placebo. Design: 2 weeks run-in followed by either THD 1 g daily or placebo, each intervention 5 weeks. Aorta–femoral artery PWV, blood pressure and plasma lipids were measured after run-in, THD and placebo.

      Results

      PWV was significantly reduced (signifying diminished central arterial stiffness): medians (25th and 75th%), placebo 9.9 m/s (8.7, 11.1), THD 8.8 m/s (7.9, 10.9); RM ANOVA P = 0.023, with Tukey procedure P < 0.05. Systolic blood pressure was significantly reduced: means (S.D.), placebo 125.6 (14.7), THD 121.3 (12.2) mmHg; Tukey P < 0.05. Plasma cholesterol, triglyceride and LDL cholesterol did not differ significantly. Absorption of THD >80% substantially exceeded that of parent isoflavones.

      Conclusion

      A metabolite normally formed after consumption of isoflavones (formononetin, daidezein), taken orally, reduced blood pressure and central arterial stiffness indicating reduced cardiovascular risk.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Gatzka C.D.
        • Cameron J.D.
        • Kingwell B.A.
        • Dart A.M.
        Relation between coronary artery disease, aortic stiffness, and left ventricular stiffness in a population sample.
        Hypertension. 1998; 32: 575-578
        View in Article
        • Blacher J.
        • Asmar R.
        • Djane S.
        • London G.M.
        • Safar M.E.
        Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients.
        Hypertension. 1999; 33: 1111-1117
        View in Article
        • Sutton-Tyrrell K.
        • Najjar S.S.
        • Boudreau R.M.
        • et al.
        Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
        Circulation. 2005; 111: 3384-3390
        View in Article
        • Safar M.E.
        • Levy B.I.
        • Struilker-Boudier H.
        Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases.
        Circulation. 2003; 107: 2864-2869
        View in Article
        • Lehmann E.D.
        • Hopkins K.D.
        • Rawesh A.
        • et al.
        Relation between number of cardiovascular risk factors/events and non-invasive Doppler ultrasound assessments of aortic compliance.
        Hypertension. 1998; 32: 565-569
        View in Article
        • Shengxu Li
        • Chen W.
        • Srinivasan R.
        • Berenson G.S.
        Influence of metabolic syndrome on arterial stiffness and its age-related change in young adults: the Bogalusa study.
        Atherosclerosis. 2005; 180: 349-354
        View in Article
        • McGrath B.P.
        • Liang Y.L.
        • Teede H.
        • Shiel L.M.
        • Cameron J.D.
        • Dart A.M.
        Age-related deterioration in arterial structure and function in postmenopausal women. Impact of hormone replacement therapy.
        Arterisocler Thromb Vasc Biol. 1998; 18: 1149-1156
        View in Article
        • Rajkumar C.
        • Kingwell B.A.
        • Cameron J.D.
        • Waddell T.
        • Mehra R.
        • Christophidis N.
        1997 Hormonal therapy increases arterial compliance in postmenopausal women.
        J Am Coll Cardiol. 1997; 30: 350-356
        View in Article
        • Nestel P.J.
        • Yamashita T.
        • Sasahara T.
        • et al.
        Soy isoflavones improve arterial compliance but not plasma lipids in menopausal women.
        Arterioscler Thromb Vasc Biol. 1997; 17: 3392-3398
        View in Article
        • Nestel P.J.
        • Pomeroy S.
        • Kay S.
        • et al.
        Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women.
        J Clin Endocrinol Metab. 1999; 84: 895-898
        View in Article
        • Teede H.J.
        • McGrath B.P.
        • DeSilva L.
        • Cehun M.
        • Fassoulakis A.
        • Nestel P.J.
        Isoflavones reduce arterial stiffness. A placebo controlled study in men and postmenopausal women.
        Arterioscler Thromb Vasc Biol. 2003; 23: 1066-1071
        View in Article
        • Setchell K.D.R.
        Phytoestrogens: the biochemistry, physiology and implications for human health of soy isoflavones.
        Am J Clin Nutr. 1998; 68: 1333S-1346S
        View in Article
        • Chin-Dusting J.P.F.
        • Boak L.
        • Husband A.
        • Nestel P.J.
        The isoflavone dehydroequol produces vasodilatation in human resistance arteries via a nitric oxide-dependent mechanism.
        Atherosclerosis. 2004; 176: 45-48
        View in Article
        • Chin-Dusting J.P.F.
        • Fisher L.J.
        • Lewis T.V.
        • Piekarska A.
        • Nestel P.J.
        • Husband A.
        The vascular activity of some isoflavone metabolites: implications for a cardioprotective role.
        Br J Pharmacol. 2001; 133: 595-605
        View in Article
        • Setchell K.D.
        • Brown N.M.
        • Lydeking-Olson E.
        The clinical importance of the metabolite equol—a clue to the effectiveness of soy and its isoflavones.
        J Nutr. 2002; 132: 577-584
        View in Article
        • Tsunoda N.
        • Pomeroy S.
        • Nestel P.
        Absorption in humans of isoflavones from soy and red clover is similar.
        J Nutr. 2002; 132: 2199-2201
        View in Article
        • Joannou G.E.
        • Kelly G.E.
        • Reeder A.Y.
        • Waring M.
        • Nelson C.
        A urinary profile of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids.
        J Steroid Biochem Molec Biol. 1995; 54: 167-184
        View in Article
        • Kanellakis P.
        • Nestel P.
        • Bobik A.
        Angioplasty-induced superoxide anions and neointimal hyperplasia in the rabbit carotid artery: suppression by the isoflavone trans-tetrahydrodaidzein.
        Atherosclerosis. 2004; 176: 63-72
        View in Article

      19. International Diabetes Federation. Consensus on worldwide definition of the metabolic syndrome. 2005.

        View in Article
        • Liang Y.L.
        • Teede H.
        • Kotsopoulos D.
        • et al.
        Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size.
        Clin Sci. 1998; 95: 669-679
        View in Article
        • Teede H.
        • Dalais F.
        • Kotsopoulos D.
        • Liang Y.L.
        • McGrath B.P.
        Soy protein dietary supplementation containing phytoestrogens improve lipid profiles and blood pressure: a double-blind, randomized, placebo controlled study in men and postmenopausal women.
        J Clin Endocrinol Metab. 2001; 86: 3053-3060
        View in Article
        • Van der Schouw Y.T.
        • Pijpe A.
        • Lebrun C.E.I.
        • et al.
        Higher usual dietary intake of Phytoestrogens is associated with lower aortic stiffness in postmenopausal women.
        Arterioscler Thromb Vasc Biol. 2002; 22: 1316-1322
        View in Article
        • Sawabe M.
        • Takahashi R.
        • Matsushita S.
        • et al.
        Aortic pulse wave velocity and the degree of atherosclerosis in elderly: a pathological study based on 304 autopsy cases.
        Atherosclerosis. 2005; 179: 345-351
        View in Article
        • Zieman S.J.
        • Melenovsky V.
        • Kaas D.A.
        Mechanisms, pathophysiology, and therapy of arterial stiffness.
        Arterisocler Thromb Vasc Biol. 2005; 25: 932-943
        View in Article
        • Toikka J.O.
        • Niemi P.
        • Ahotupa M.
        • et al.
        Large-artery elastic properties in young men. Relationship to serum lipoproteins and oxidized low-density lipoproteins.
        Arterioscler Thromb Vasc Biol. 1999; : 436-441
        View in Article
        • McEniery Y.C.M.
        • Wallace S.
        • Mackenzie I.S.
        • Cockroft J.R.
        • Wilkinson I.B.
        C-reactive protein is associated with arterial stiffness in apparently healthy Individuals.
        Arterioscler Thromb Vasc Biol. 2004; 24: 969-974
        View in Article
        • Squadrito F.
        • Altavilla D.
        • Morabito N.
        • et al.
        The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium-dependent vasodilation in postmenopausal women.
        Atherosclerosis. 2002; 163: 339-347
        View in Article

      Article info

      Publication history

      Published online: May 28, 2006
      Accepted: April 28, 2006
      Received in revised form: April 26, 2006
      Received: February 26, 2006

      Identification

      DOI: https://doi.org/10.1016/j.atherosclerosis.2006.04.033

      Copyright

      © 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX