Abstract
Objectives
Isoflavones reduce arterial stiffness, a predictor of cardiovascular events. Whether
metabolites of isoflavones have similar bioactivity is unknown. The effect of supplemental
trans-tetrahydrodaidzein (THD) a metabolite of daidzein on pulse wave velocity (PWV),
a measure of arterial stiffness was tested in overweight men and postmenopausal women.
Methods
25 subjects, 11 postmenopausal women, 14 men (age, 57 [7] years; body mass index,
30.3 [4.7] kg/m2; mean [S.D.]) participated in a double-blind, randomized, cross-over trial of THD
versus placebo. Design: 2 weeks run-in followed by either THD 1 g daily or placebo, each intervention 5 weeks. Aorta–femoral artery PWV, blood pressure
and plasma lipids were measured after run-in, THD and placebo.
Results
PWV was significantly reduced (signifying diminished central arterial stiffness):
medians (25th and 75th%), placebo 9.9 m/s (8.7, 11.1), THD 8.8 m/s (7.9, 10.9); RM ANOVA P = 0.023, with Tukey procedure P < 0.05. Systolic blood pressure was significantly reduced: means (S.D.), placebo 125.6
(14.7), THD 121.3 (12.2) mmHg; Tukey P < 0.05. Plasma cholesterol, triglyceride and LDL cholesterol did not differ significantly.
Absorption of THD >80% substantially exceeded that of parent isoflavones.
Conclusion
A metabolite normally formed after consumption of isoflavones (formononetin, daidezein),
taken orally, reduced blood pressure and central arterial stiffness indicating reduced
cardiovascular risk.
Keywords
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Article Info
Publication History
Published online: May 28, 2006
Accepted:
April 28,
2006
Received in revised form:
April 26,
2006
Received:
February 26,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
