We thank Drs. Brendsel and Green for their thoughtful comments on our review of phytosterols.
We share their concern that phytosterol dietary supplementation could increase atherosclerotic
risk, but we are reassured by the ability of plant stanols and sterols to reduce circulating
cholesterol levels. As detailed in our review, circulating phytosterols should increase
blood cholesterol measurements. In contrast, presently available agents reduce blood
cholesterol levels suggesting that they are not absorbed and therefore could not contribute
to atherosclerotic risk. This issue is not settled, however, and additional research
on this question is required to address the question of atherosclerotic risk with
these agents.
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Article info
Publication history
Published online: September 29, 2006
Received:
August 14,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
