Abstract
Serotonin (5-HT), a potent vasoconstrictor in the large cerebral arteries, is considered
to play a key role in atherothrombosis and to be implicated in ischemic cerebrovascular
events followed by delayed neuronal death. The present study aims at evaluating the
relationship between plasma levels of 5-HT and vascular dementia (VaD) caused by stroke
or atherosclerotic small vessel disease. Carotid artery intima-media thickness (IMT),
plaques, plasma 5-HT levels and atherosclerotic parameters were determined in 20 patients
with VaD and 40 age-matched controls. Age, gender, body mass index, systolic and diastolic
blood pressure, fasting plasma glucose levels and serum levels of insulin, triglycerides,
high-density lipoprotein cholesterol, leptin, adiponectin and interleukin-6 and plasma
levels of plasminogen activator inhibitor-1 were not significantly different between
the two groups. Serum levels of insulin-like growth factor-1 (IGF-1) were significantly
lower in VaD patients than in controls. Plasma 5-HT levels, serum levels of hepatocyte
growth factor (HGF), low-density lipoprotein (LDL) cholesterol and high-sensitive
C-reactive protein (hs-CRP), max IMT and plaque frequency were significantly greater
in VaD patients than in controls. There was a significant positive correlation of
max IMT with 5-HT or HGF levels. Multiple logistic regression analysis revealed that
increased plasma levels of 5-HT and carotid plaque prevalence had significantly independent
association with VaD as compared with serum levels of IGF-1, HGF, LDL cholesterol
and hs-CRP. These results suggest that increased plasma levels of 5-HT and carotid
atherosclerotic plaques may be involved in the pathogenesis and progression of VaD.
Keywords
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Article info
Publication history
Published online: October 20, 2006
Accepted:
September 8,
2006
Received in revised form:
August 31,
2006
Received:
July 6,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
