Abstract
Background
The Japanese–Brazilian Diabetes Study detected high prevalence of metabolic syndrome
(MS) in a population of Japanese ancestry living in Brazil. We describe the prevalence
of macrovascular disease (MVD) and its association with classical and non-classical
cardiovascular risk factors in this population.
Methods
An overall of 1163 individuals were studied; diagnosis of MVD was based on a score
obtained from medical history, ankle-brachial pressure index and electrocardiogram,
defining three groups: no MVD, possible MVD and definite MVD.
Results
Prevalence of MVD was 14.3% (possible MVD: 11.2%; definite MVD: 3.1%). Individuals
with MS had higher rates of MVD (16.9% versus 11.2%; p < 0.05). Comparing to no MVD, age, 2 h plasma glucose, anti-LDL(+) and anti-LDL(−) levels, and urinary albumin-to-creatinine
ratio were higher in both categories with MVD; waist-to-hip ratio, fasting plasma
glucose, HbA1c, total-to-HDL cholesterol ratio and triglycerides were higher in that
with definite MVD; systolic blood pressure and homocysteine were higher in that with
possible MVD. Using logistic regression, systolic blood pressure, smoking habit and
anti-LDL(+) were independently associated with MVD.
Conclusion
MVD is highly prevalent in Japanese–Brazilians and its association with MS was confirmed.
A novel marker of lipoprotein modifications – anti-LDL(+) antibody – could be useful
in identifying individuals at higher risk.
Keywords
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Article info
Publication history
Published online: October 25, 2006
Accepted:
September 13,
2006
Received in revised form:
August 11,
2006
Received:
July 5,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
