Abstract
Stent restenosis remains the main limitation of percutaneous coronary intervention.
Elevated serum gamma-glutamyl transferase (GGT) level is associated with an inflammatory
response. We aimed to determine the correlation of stent restenosis with the serums
level of GGT. One hundred and twenty patients (age 58.56 ± 10.46 years, 66% male) with a history of coronary stent implantation and had undergone
control coronary angiography (60 with restenosis and 60 without) were included. All
had baseline serum GGT activity and were free of systemic and hepatobiliary disease.
Median baseline serum GGT activity was significantly higher in patients with restenosis
(34.00 U/L (24.00–47.75)) than in those without restenosis (21.00 U/L (17.25–26.7500)) (P < 0.0001). Stent restenosis was identified in 38% of the patients with a serum GGT value
>40 U/L and in 5% of patients with a serum GGT value ≤40 U/L (P < 0.001). Serum C-reactive protein (CRP) and total bilirubin levels were significantly
higher (P = 0.011 and 0.037, respectively) and alkaline phosphatase levels were significantly
lower in patients with restenosis (P = 0.029). Levels of GGT, CRP, and alkaline phosphatase were independent predictors of
restenosis (P = 0.001, 0.019 and 0.004, respectively). In conclusion, the serum level of GGT may be
an independent marker for stent restenosis.
Keywords
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Article info
Publication history
Published online: November 08, 2006
Accepted:
September 27,
2006
Received in revised form:
September 12,
2006
Received:
April 15,
2006
Footnotes
☆This study was presented at the XIV International Congress of Atherosclerosis, Roma, Italy, June 18–22, 2006.
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
