Advertisement

Hepatitis B virus seropositivity is not associated with increased risk of carotid atherosclerosis in Taiwanese

  • Kai-Chien Yang
    Affiliations
    Division of Cardiology of the Department of Internal Medicine, E-Da Hosptial, Kaohsiung, Taiwan

    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author
  • Ming-Fong Chen
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author
  • Ta-Chen Su
    Correspondence
    Corresponding author. Tel.: +886 2 23123456x6719; fax: +886 2 23712361.
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author
  • Jiann-Shing Jeng
    Affiliations
    Department of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for articles by this author
  • Bau-Show Hwang
    Affiliations
    Department of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
    Search for articles by this author
  • Lian-Yu Lin
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author
  • Chiau-Suong Liau
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author
  • Yuan-Teh Lee
    Affiliations
    Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan S. Road, Taipei, Taiwan
    Search for articles by this author

      Abstract

      Background

      Chronic infection has been proposed to increase the risk of atherosclerosis in several experimental and epidemiological studies. However, the relationship of chronic hepatitis B virus (HBV) infection and atherosclerosis remains controversial. We conducted this cross-sectional study to evaluate the association of carotid atherosclerosis with hepatitis B seropositivity.

      Methods and results

      In this cross-sectional study, we collected data from subjects undergoing health examination, including B-mode carotid ultrasonography, hepatitis B surface antigen (HBsAg) status and assessment of traditional cardiovascular risk factors, at our institutes in Taiwan between 2002 and 2003. Cases with chronic hepatitis C had been excluded. Of the 508 eligible subjects, 87 (17.1%) were positive for HBsAg and only six of them were positive for HBeAg. Compared with HBsAg negative subjects, the ORs (and 95% CIs) for the subjects with chronic hepatitis B to have carotid atherosclerosis were 1.24 (0.73–2.10) indexed by the presence of carotid atherosclerotic plaque (Intima-media thickness, IMT ≥ 1.3 mm), 0.74 (0.38–1.42) by maximal common carotid artery IMT ≥ 75th percentile, and 1.09 (0.62–1.90) by extracranial carotid artery atherosclerotic score ≥ 2, with the use of multivariate logistic regression analyses.

      Conclusion

      Hepatitis B virus seropositivity was not associated with an increased severity of carotid atherosclerosis in Taiwanese.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Saikku P.
        Epidemiology of Chlamydia pneumoniae in atherosclerosis.
        Am Heart J. 1999; 138: S500-S503
        • Mendall M.A.
        • Goggin P.M.
        • Molineaux N.
        • et al.
        Relation of Helicobacter pylori infection and coronary heart disease.
        Brit Heart J. 1994; 71: 437-439
        • Adam E.
        • Melnick J.L.
        • Probtsfield J.L.
        • et al.
        High levels of cytomegalovirus antibody in patients requiring vascular surgery for atherosclerosis.
        Lancet. 1987; 2: 291-293
        • Yamashiroya H.M.
        • Ghosh L.
        • Yang R.
        • Robertson Jr., A.L.
        Herpesviridae in the coronary arteries and aorta of young trauma victims.
        Am J Pathol. 1988; 130: 71-79
        • Zhu J.
        • Quyyumi A.A.
        • Norman J.E.
        • et al.
        The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.
        J Infect Dis. 2000; 182: 1583-1587
        • Su T.C.
        • Cheng T.J.
        • Lee Y.T.
        • et al.
        Chronic hepatitis B virus infection and dyslipidemia.
        J Fomos Med Assoc. 2004; 103: 286-291
        • Volzke H.
        • Schwahn C.
        • Wolff B.
        • et al.
        Hepatitis B and C virus infection and the risk of atherosclerosis in a general population.
        Atherosclerosis. 2004; 174: 99-103
        • Ishizaka N.
        • Ishizaka Y.
        • Takahashi E.
        • et al.
        Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers.
        Circulation. 2002; 105: 1028-1030
        • Tomiyama H.
        • Arai T.
        • Hirose K.
        • et al.
        Hepatitis C virus seropositivity, but not hepatitis B virus carrier or seropositivity, associated with increased pulse wave velocity.
        Atherosclerosis. 2003; 166: 401-403
        • Bilora F.
        • Rinaldi R.
        • Boccioletti V.
        • et al.
        Chronic viral hepatitis: a prospective factor against atherosclerosis. A study with echo-color Doppler of the carotid and femoral arteries and the abdominal aorta.
        Gastroenterol Clin Biol. 2002; 26: 1001-1004
        • Wieland H.
        • Seidel D.
        A simple specific method for precipitation of low density lipoproteins.
        J Lipid Res. 1983; 24: 904-909
        • Su T.C.
        • Jeng J.S.
        • Chien K.L.
        • et al.
        Hypertension status is the major determinant of carotid atherosclerosis: a community-based study in Taiwan.
        Stroke. 2001; 32: 2265-2271
        • Su T.C.
        • Jeng J.S.
        • Chien K.L.
        • et al.
        Measurement reliability of common carotid artery intima-media thickness by ultrasonographic assessment.
        J Med Ultrasound. 1999; 7: 73-79
        • Su T.C.
        • Jeng J.S.
        • Wang J.D.
        • et al.
        Homocysteine, circulating vascular cell adhesion molecule and carotid atherosclerosis in postmenopausal vegetarian women and omnivores.
        Atherosclerosis. 2006; 184: 356-362
        • Su T.C.
        • Chien K.L.
        • Jeng J.S.
        • et al.
        Pulse pressure, aortic regurgitation and carotid atherosclerosis: a comparison between hypertensives and normotensives.
        Int J Clin Pract. 2006; 60: 134-140
        • Chen C.C.
        • Chung M.Y.
        • Jeng J.S.
        • et al.
        A scoring system for evaluation of the extent of extracranial carotid atherosclerosis with B-mode imaging.
        Acta Neural Sin. 1995; 4: 29-33
        • Sung J.L.
        • Hepatitis
        B virus infection and its sequelae in Taiwan.
        Gastroenterol Jpn. 1984; 19: 363-366
        • Chen D.S.
        • Sung J.L.
        • Hepatitis
        B virus infection and chronic liver disease in Taiwan.
        Acta Hepatogastroenterol. 1978; 25: 423-430
        • Mason A.
        • Wick M.
        • White H.
        • Perrillo R.
        • Hepatitis
        B virus replication in diverse cell types during chronic hepatitis B virus infection.
        Hepatology. 1993; 18: 781-789
        • Guillevin L.
        Virus-associated vasculitides. vol. 38. Rheumatology, Oxford1999 (p. 588–590)
        • Kiechl S.
        • Egger G.
        • Mayr M.
        • et al.
        Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study.
        Circulation. 2001; 103: 1064-1070
        • Nakamura T.
        • Nishizawa T.
        • Hagiya M.
        • et al.
        Molecular cloning and expression of human hepatocyte growth factor.
        Nature. 1989; 342: 440-443
        • Shiota G.
        • Okano J.
        • Kawasaki H.
        • et al.
        Serum hepatocyte growth factor levels in liver diseases: clinical implications.
        Hepatology. 1995; 21: 106-112
        • Marchesini G.
        • Ronchi M.
        • Forlani G.
        • et al.
        Cardiovascular disease in cirrhosis--a point-prevalence study in relation to glucose tolerance.
        Am J Gastroenterol. 1999; 94: 655-662
        • Ferrari C.
        • Penna A.
        • Bertoletti A.
        • et al.
        Antiviral cell-mediated immune responses during hepatitis B and hepatitis C virus infections.
        Recent Results Cancer Res. 1998; 154: 330-336