Abstract
We examined the effect of chronic social stress, similar to that endured by humans,
on lipid metabolism of mice. The activity of the lipoprotein lipase (LPL) enzyme increased
in adrenals, while in plasma it diminished significantly. Hepatic lipase (HL) was
strongly affected in liver and adrenal glands, increasing four-fold and three-fold,
respectively. At the same time, scavenger receptor class-B type-I (SR-BI), which are
considered the high-density lipoprotein (HDL) receptor in the liver, increased significantly.
Although the adrenals do not synthesise HL, the increase in HL may facilitate the
uptake of HDL cholesterol for the synthesis of corticoids, which increase significantly
following chronic stress. The volume of adrenal glands in control animals was significantly
higher than in stressed animals (1.23 ± 0.12 mm3 versus 0.29 ± 0.06 mm3, p < 0.001), corresponding with the weight difference of these organs. Medulla volume was
also different in the two groups (0.27 ± 0.10 mm3 versus 0.04 ± 0.02 mm3, p < 0.05). Despite this, corticosterone in plasma was significantly higher in stressed
animals.
Our results shows, for the first time, the effect of chronic social stress on lipid
metabolism in general, and in particular on the SR-BI receptor and HL, which is directly
involved in cholesterol reverse transport.
Keywords
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Article info
Publication history
Published online: January 12, 2007
Accepted:
November 29,
2006
Received in revised form:
October 27,
2006
Received:
July 26,
2006
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
