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Relation of self-reported sleep duration with carotid intima-media thickness in a general population sample

      Abstract

      Objectives

      An association of sleep with cardiovascular disease has been suggested. We analyzed the association of sleep duration with carotid intima-media thickness (IMT) as measure of generalized atherosclerosis.

      Methods

      IMT of the common carotid arteries was measured in 2437 participants of the Study of Health in Pomerania (SHIP). Participants indicated their daily sleep duration as sum of night and afternoon sleep.

      Results

      There was a J-shaped association of sleep duration (5 to 11/12 h) with IMT. In this association, IMT values were lowest among subjects with an average sleep duration of 7–8 h (0.76 ± 0.15 and 0.79 ± 0.16 mm, respectively) but increased with shorter and, still more so, with longer sleep duration. Subjects with only 5 h sleep showed age- and sex-adjusted differences of 0.042 mm IMT (95% confidence interval 0.008–0.076 versus 8 h sleep). IMT values were still greater among subjects with 11–12 h sleep (adjusted differences versus 8 h sleep 0.084 mm [0.040–0.128] IMT). Further adjustment for lifestyle indicators, socioeconomic determinants, and biological variables attenuated these differences, but they remained significant.

      Conclusions

      Both longer and shorter sleep duration is associated with an increased risk of atherosclerosis. These findings support the hypothesis that sleep is related to cardiovascular disease.

      Keywords

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      References

        • Mitler M.M.
        • Miller J.C.
        • Lipsitz J.J.
        • et al.
        The sleep of long-haul truck drivers.
        N Engl J Med. 1997; 337: 755-761
        • Krueger J.M.
        • Majde J.A.
        Humoral links between sleep and the immune system: research issues.
        Ann NY Acad Sci. 2003; 992: 9-20
        • Somers V.K.
        • Dyken M.E.
        • Mark A.L.
        • et al.
        Sympathetic-nerve activity during sleep in normal subjects.
        N Engl J Med. 1993; 328: 303-307
        • Elsenbruch S.
        • Harnish M.J.
        • Orr W.C.
        Heart rate variability during waking and sleep in healthy males and females.
        Sleep. 1999; 22: 1067-1071
        • Monti A.
        • Medigue C.
        • Nedelcoux H.
        • et al.
        Autonomic control of the cardiovascular system during sleep in normal subjects.
        Eur J Appl Physiol. 2002; 87: 174-181
        • Heiser P.
        • Dickhaus B.
        • Opper C.
        • et al.
        Platelet serotonin and interleukin-1 beta after sleep deprivation and recovery sleep in humans.
        J Neural Transm. 1997; 104: 1049-1058
        • Irokawa M.
        • Nishinaga M.
        • Funayama H.
        • et al.
        Effect of a change in the sleep/wake cycle on the diurnal variation of fibrinolytic parameters.
        J Thromb Thrombolysis. 1998; 5: 165-168
        • Muller J.E.
        • Tofler G.H.
        • Stone P.H.
        Circadian variation and triggers of onset of acute cardiovascular disease.
        Circulation. 1989; 79: 733-743
        • Heslop P.
        • Smith G.D.
        • Metcalfe C.
        • et al.
        Sleep duration and mortality: the effect of short or long sleep duration on cardiovascular and all-cause mortality in working men and women.
        Sleep Med. 2002; 3: 305-314
        • Gangwisch J.E.
        • Heymsfield S.B.
        • Boden-Albala B.
        • et al.
        Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey.
        Hypertension. 2006; 47: 833-839
        • Gottlieb D.J.
        • Redline S.
        • Nieto F.J.
        • et al.
        Association of usual sleep duration with hypertension: the Sleep Heart Health Study.
        Sleep. 2006; 29: 1009-1014
        • Burazeri G.
        • Gofin J.
        • Kark J.D.
        Over 8 h of sleep-marker of increased mortality in Mediterranean population: follow-up population study.
        Croat Med J. 2003; 44: 193-198
        • Qureshi A.I.
        • Giles W.H.
        • Croft J.B.
        • et al.
        Habitual sleep patterns and risk for stroke and coronary heart disease: a 10-year follow-up from NHANES I.
        Neurology. 1997; 48: 904-911
        • Wingard D.L.
        • Berkman L.F.
        Mortality risk associated with sleeping patterns among adults.
        Sleep. 1983; 6: 102-107
        • Patel S.R.
        • Ayas N.T.
        • Malhotra M.R.
        • White D.P.
        • Schernhammer E.S.
        • Speizer F.E.
        • Stampfer M.J.
        • Hu F.B.
        A prospective study of sleep duration and mortality risk in women.
        Sleep. 2004; 27: 440-444
        • Ayas N.T.
        • White D.P.
        • Manson J.E.
        • et al.
        A prospective study of sleep duration and coronary heart disease in women.
        Arch Intern Med. 2003; 163: 205-209
        • Ayas N.T.
        • White D.P.
        • Al-Delaimy W.K.
        • et al.
        A prospective study of self-reported sleep duration and incident diabetes in women.
        Diabetes Care. 2003; 26: 380-384
        • Luedemann J.
        • Schminke U.
        • Berger K.
        • et al.
        Association between behavior-dependent cardiovascular risk factors and asymptomatic carotid atherosclerosis in a general population.
        Stroke. 2002; 33: 2929-2935
        • Shamsuzzaman A.S.
        • Gersh B.J.
        • Somers V.K.
        Obstructive sleep apnea: implications for cardiac and vascular disease.
        JAMA. 2003; 290: 1906-1914
        • Young T.
        • Palta M.
        • Dempsey J.
        • et al.
        The occurrence of sleep-disordered breathing among middle-aged adults.
        N Engl J Med. 1993; 328: 1230-1235
        • Wannamethee G.
        • Shaper A.G.
        • Walker M.
        Physical activity and mortality in older men with diagnosed coronary heart disease.
        Circulation. 2000; 102: 1358-1363
        • Manson J.E.
        • Greenland P.
        • LaCroix A.Z.
        • et al.
        Walking compared with vigorous exercise for the prevention of cardiovascular events in women.
        N Engl J Med. 2002; 347: 716-725
        • Gangwisch J.E.
        • Malaspina D.
        • Boden-Albala B.
        • et al.
        Inadequate sleep as a risk factor for obesity: analyses of the NHANES I.
        Sleep. 2005; 28: 1289-1296
        • Kato M.
        • Phillips B.G.
        • Sigurdsson G.
        • et al.
        Effects of sleep deprivation on neural circulatory control.
        Hypertension. 2000; 35: 1173-1175
        • Irwin M.
        • Thompson J.
        • Miller C.
        • et al.
        Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications.
        J Clin Endocrinol Metab. 1999; 84: 1979-1985
        • Redwine L.
        • Hauger R.L.
        • Gillin J.C.
        • et al.
        Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
        J Clin Endocrinol Metab. 2000; 85: 3597-3603
        • Spiegel K.
        • Leproult R.
        • Van Cauter E.
        Impact of sleep debt on metabolic and endocrine function.
        Lancet. 1999; 354: 1435-1439