Serum magnesium and lipids: More clarity is needed

      In their recent paper, Randell et al. reported that serum magnesium levels were directly correlated with total, HDL- and LDL-cholesterol in a large adult study population [

      Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis 2006; doi:10.1016/j.atherosclerosis.2006.11.024.

      ]. This paper is very interesting, and the possibility that the relationship between magnesium and lipoproteins in healthy subjects may have different meaning from that in diabetic patients merits attention. Furthermore, we agree that a binding interaction between magnesium and lipoprotein could at least partially account for these results. However, as the authors acknowledged, this binding interaction may diminish the utility of serum total magnesium measurement as an indicator of magnesium status. The fact that plasma albumin qualified as the main correlate of serum total magnesium is neither novel nor surprising, and seems to confirm this hypothesis.


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      1. Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis 2006; doi:10.1016/j.atherosclerosis.2006.11.024.

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