In their recent paper, Randell et al. reported that serum magnesium levels were directly
correlated with total, HDL- and LDL-cholesterol in a large adult study population
[
[1]
]. This paper is very interesting, and the possibility that the relationship between
magnesium and lipoproteins in healthy subjects may have different meaning from that
in diabetic patients merits attention. Furthermore, we agree that a binding interaction
between magnesium and lipoprotein could at least partially account for these results.
However, as the authors acknowledged, this binding interaction may diminish the utility
of serum total magnesium measurement as an indicator of magnesium status. The fact
that plasma albumin qualified as the main correlate of serum total magnesium is neither
novel nor surprising, and seems to confirm this hypothesis.Keywords
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References
Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis 2006; doi:10.1016/j.atherosclerosis.2006.11.024.
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Publication history
Published online: April 05, 2007
Received:
January 6,
2007
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© 2007 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
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- Positive correlation between total serum magnesium and serum lipid levels in the general population is clear: Ionized magnesium remains to be examinedAtherosclerosisVol. 192Issue 1
- PreviewWe appreciate the comments made by Dr. Corsonello and co-workers but will now address some of the concerns raised by this group. There were questions regarding the population used and the probability of there being high rates of insulin resistance. The study is population based with the only specific limitations on participation being age, inability to attend for blood collection and dual-energy X-ray absorptiometry (DEXA), and presence of severe metabolic, cardiovascular or endocrine disorders.
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