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Serum magnesium and lipids: More clarity is needed

      In their recent paper, Randell et al. reported that serum magnesium levels were directly correlated with total, HDL- and LDL-cholesterol in a large adult study population [

      Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis 2006; doi:10.1016/j.atherosclerosis.2006.11.024.

      ]. This paper is very interesting, and the possibility that the relationship between magnesium and lipoproteins in healthy subjects may have different meaning from that in diabetic patients merits attention. Furthermore, we agree that a binding interaction between magnesium and lipoprotein could at least partially account for these results. However, as the authors acknowledged, this binding interaction may diminish the utility of serum total magnesium measurement as an indicator of magnesium status. The fact that plasma albumin qualified as the main correlate of serum total magnesium is neither novel nor surprising, and seems to confirm this hypothesis.

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      References

      1. Randell EW, Mathews M, Gadag V, Zhang H, Sun G. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis 2006; doi:10.1016/j.atherosclerosis.2006.11.024.

        • Corica F.
        • Corsonello A.
        • Buemi M.
        • et al.
        Platelet magnesium depletion in normotensive and hypertensive obese subjects: the role of salt-regulating hormones and catecholamines.
        Magnes Res. 1999; 12: 287-296
        • Corica F.
        • Allegra A.
        • Ientile R.
        • et al.
        Changes in plasma, erythrocyte, and platelet magnesium levels in normotensive and hypertensive obese subjects during oral glucose tolerance test.
        Am J Hypertens. 1999; 12: 128-136
        • Durlach J.
        • Rayssiguier Y.
        Magnésium et glucides, II. Données cliniques et thérapeutiques.
        Magnesium. 1983; 2: 192-224
        • Resnick L.M.
        • Gupta R.K.
        • Bhargava K.K.
        • et al.
        Cellular ions in hypertension, diabetes, and obesity: a nuclear magnetic resonance spectroscopic study.
        Hypertension. 1991; 17: 951-957
        • Resnick L.M.
        Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders: mechanism of syndrome X.
        Am J Hypertens. 1993; 6: 123S-134S
        • Paolisso G.
        • Barbagallo M.
        Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium.
        Am J Hypertens. 1997; 10: 346-355
        • Corica F.
        • Corsonello A.
        • Ientile R.
        • et al.
        Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients.
        J Am Coll Nutr. 2006; 25: 210-215
        • Corsonello A.
        • Ientile R.
        • Buemi M.
        • et al.
        Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria.
        Am J Nephrol. 2000; 20: 187-192
        • Haenni A.
        • Ohrvall M.
        • Lithell H.
        Atherogenic li pid fractions are related to ionized magnesium status.
        Am J Clin Nutr. 1998; 67: 202-207
        • Resnick L.M.
        • Altura B.T.
        • Gupta R.K.
        • et al.
        Intracellular and extracellular magnesium depletion in type II (non insulin-dependent) diabetes mellitus.
        Diabetologia. 1993; 36: 767-770
        • Barbagallo M.
        • Gupta R.
        • Dominguez L.J.
        • Resnick L.M.
        Cellular ionic alterations with aging: relation to hypertension and diabetes.
        J Am Geriatr Soc. 2000; 48: 1111-1116
        • Robles N.R.
        • Escola J.M.
        • Albarran L.
        • Espada R.
        Correlation of serum magnesium and serum lipid levels in hemodialysis patients.
        Nephron. 1998; 78: 118-119
        • Bastida S.
        • Vaquero M.P.
        • Veldhuizen M.
        • Sanchez-Muniz F.J.
        Selected trace elements and minerals in cord blood: association with lipids and lipoproteins at birth.
        Acta Paediatr. 2000; 89: 1201-1206
        • Nozue T.
        • Kobayashi A.
        • Uemasu F.
        • et al.
        Magnesium status, serum HDL cholesterol, and apolipoprotein A-1 levels.
        J Pediatr Gastroenterol Nutr. 1995; 20: 316-318

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