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Research Article| Volume 203, ISSUE 1, P257-262, March 2009

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Association between lipid profile and circulating concentrations of estrogens in young men

      Abstract

      Objectives

      Men show higher rates of cardiovascular morbidity and mortality than pre-menopausal women and this sexual dimorphism may be related to sex-specific effects of sex steroids on cardiovascular risk factors. Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men.

      Methods

      We examined associations of estradiol and estrone and their precursors (total testosterone and androstenedione) with traditional cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age: 19 years), apparently healthy Polish men.

      Results

      Total estradiol was associated with total cholesterol (p = 0.006) and high-density lipoprotein cholesterol (HDL-C) (p < 0.001) and estrone showed the strongest associations with both total cholesterol (p < 0.001) and low-density lipoprotein cholesterol (LDL-C) (p < 0.001) in the unadjusted ANOVA analysis. In the multivariable adjusted models in which other independent variables were held as constant one standard deviation increase in estradiol level was associated with 6%-standard deviation increase in total cholesterol (standardized β = 0.06, p = 0.038) and 6%-standard deviation decrease in HDL-cholesterol (standardized β = −0.06, p = 0.036). An increase in estrone levels by one standard deviation was associated with respective 12%- and 13%-standard deviation increases in total cholesterol (standardized β = 0.12, p < 0.001) and LDL-cholesterol levels (standardized β = 0.12, p < 0.001) after controlling for other predictors of lipids. Estrone correlated linearly with androstenedione (r = 0.28, p < 0.001) but there was no correlation between estradiol and testosterone. Estrogens retained their independent associations with lipids after adjustment for their biochemical precursors in the multivariable analysis.

      Conclusions

      Increased levels of estrogens are associated with unfavourable lipid profile in men and this association is present early in life, before apparent manifestations of cardiovascular disease.

      Keywords

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      References

        • McCarthy J.J.
        Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome.
        Nutr Metab Cardiovasc Dis. 2007; 17: 153-161
        • Rosamond W.
        • Flegal K.
        • Friday G.
        • Furie K.
        • Go A.
        • Greenlund K.
        • et al.
        Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
        Circulation. 2007; 115: e69-e171
        • Charchar F.J.
        • Tomaszewski M.
        • Padmanabhan S.
        • et al.
        The Y chromosome effect on blood pressure in two European populations.
        Hypertension. 2002; 39: 353-356
        • Charchar F.J.
        • Tomaszewski M.
        • Lacka B.
        • et al.
        Association of the human Y chromosome with cholesterol levels in the general population.
        Arterioscler Thromb Vasc Biol. 2004; 24: 308-312
        • Charchar F.J.
        • Tomaszewski M.
        • Strahorn P.
        • Champagne B.
        • Dominiczak A.F.
        Y is there a risk to being male?.
        Trends Endocrinol Metab. 2003; 14: 163-168
        • Reckelhoff J.R.
        Gender differences in the regulation of blood pressure.
        Hypertension. 2001; 37: 1199-1208
        • Wu F.C.
        • von Eckardstein A.
        Androgens and coronary artery disease.
        Endocr Rev. 2003; 24: 183-217
        • Hak A.E.
        • Witteman J.C.
        • de Jong F.H.
        • et al.
        Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study.
        J Clin Endocrinol Metab. 2002; 87: 3632-3639
        • van den Beld A.W.
        • Bots M.L.
        • Janssen J.A.
        • et al.
        Endogenous hormones and carotid atherosclerosis in elderly men.
        Am J Epidemiol. 2003; 157: 25-31
        • Muller M.
        • van den Beld A.W.
        • Bots M.L.
        • et al.
        Endogenous sex hormones and progression of carotid atherosclerosis in elderly men.
        Circulation. 2004; 109: 2074-2079
        • Tivesten A.
        • Mellström D.
        • Jutberger H.
        • et al.
        Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden.
        J Am Coll Cardiol. 2007; 50: 1070-1076
        • Jeppesen L.L.
        • Jørgensen H.S.
        • Nakayama H.
        • et al.
        Decreased serum testosterone in men with acute ischemic stroke.
        Arterioscler Thromb Vasc Biol. 1996; 16: 749-754
        • Philips G.B.
        • Castelli W.P.
        • Abbott R.D.
        • McNamara P.M.
        Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort.
        Am J Med. 1983; 74: 863-869
        • Tivesten A.
        • Hulthe J.
        • Wallenfeldt K.
        • et al.
        Circulating estradiol is an independent predictor of progression of carotid artery intima-media thickness in middle-aged men.
        J Clin Endocrinol Metab. 2006; 91: 4433-4437
        • Abbott R.D.
        • Launer L.J.
        • Rodriguez B.L.
        • et al.
        Serum estradiol and risk of stroke in elderly men.
        Neurology. 2007; 68: 563-568
        • Muller M.
        • van der Schouw Y.T.
        • Thijssen J.H.
        • Grobbee D.E.
        Endogenous sex hormones and cardiovascular disease in men.
        J Clin Endocrinol Metab. 2003; 88: 5076-5086
        • Orwoll E.
        • Lambert L.C.
        • Marshall L.M.
        • et al.
        Testosterone and estradiol among older men.
        J Clin Endocrinol Metab. 2006; 91: 1336-1344
        • Gennari L.
        • Nuti R.
        • Bilezikian J.P.
        Aromatase activity and bone homeostasis in men.
        J Clin Endocrinol Metab. 2004; 89: 5898-5907
        • Feldman H.A.
        • Longcope C.
        • Derby C.A.
        • et al.
        Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study.
        J Clin Endocrinol Metab. 2002; 87: 589-598
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
        Clin Chem. 1972; 18: 499-502
        • Simpson E.R.
        Role of aromatase in sex steroid action.
        J Mol Endocrinol. 2000; 25: 149-156
        • Bogaert V.
        • Taes Y.
        • Konings P.
        • Van Steen K.
        • De Bacquer D.
        • Goemaere S.
        • et al.
        Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings.
        Clin Endocrinol. 2008; 69: 129-135
        • Mendelsohn M.E.
        • Karas R.H.
        Molecular and cellular basis of cardiovascular gender differences.
        Science. 2005; 308: 1583-1587
        • Mitchell B.D.
        • Kammerer C.M.
        • Blangero J.
        • et al.
        Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart study.
        Circulation. 1996; 94: 2159-2170
        • Porkka K.V.
        • Viikari J.S.
        • Taimela S.
        • Dahl M.
        • Akerblom H.K.
        Tracking and predictiveness of serum lipid and lipoprotein measurements in childhood: a 12-year follow-up. The cardiovascular risk in Young Finns study.
        Am J Epidemiol. 1994; 140: 1096-1110
        • Raitakari O.T.
        • Juonala M.
        • Kähönen M.
        • et al.
        Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the cardiovascular risk in Young Finns study.
        JAMA. 2003; 290: 2277-2283
        • Juonala M.
        • Jarvisalo M.J.
        • Maki-Torkko N.
        • et al.
        Risk factors identified in childhood and decreased carotid artery elasticity in adulthood: the cardiovascular risk in Young Finns study.
        Circulation. 2005; 112: 1486-1493
        • Kaufman J.M.
        • Vermeulen A.
        The decline of androgen levels in elderly men and its clinical and therapeutic implications.
        Endocr Rev. 2005; 26: 833-876
        • Shearman A.M.
        • Demissie S.
        • Cupples L.A.
        • et al.
        Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level.
        Hum Mol Genet. 2005; 14: 2405-2413
        • Pietrobelli A.
        • Faith M.S.
        • Allison D.B.
        • et al.
        Body mass index as a measure of adiposity among children and adolescents: a validation study.
        J Pediatr. 1998; 132: 204-210