Abstract
Background
Fatty acid (FA) composition in serum has been associated with C-reactive protein (CRP),
but associations with other markers of inflammation and endothelial function, e.g.
adhesion molecules are unknown. We recently suggested a possible role of the lipogenic
enzyme stearoyl coenzymeA desaturase-1 (SCD-1) in inflammation. This study investigates
the associations between serum FA composition, including SCD-1 index, and various
inflammatory and endothelial function markers.
Methods
264 Swedish men and women aged 70 years participated in this cross-sectional population-based
study. FA composition was measured in serum cholesteryl esters and was correlated
to inflammatory markers (CRP, interleukin [IL]-2, IL-6, IL-8, tumor necrosis factor
[TNF]-α, vascular cellular adhesion molecule [VCAM]-1, intercellular adhesion molecule
[ICAM]-1, E-selectin, P-selectin, L-selectin, interferon-γ, and monocyte chemoattractant
protein [MCP]-1), using linear regression analysis. SCD-1 activity was estimated by
FA product-to-precursor ratio (16:1/16:0).
Results
Serum FA composition was significantly associated with CRP and E-selectin but not
with other inflammatory markers. After adjusting for BMI, smoking, physical activity,
alcohol consumption and lipid-lowering therapy, the proportion of palmitoleic acid
and SCD-1 index were positively correlated with CRP concentrations (P = 0.003 and P = 0.001, respectively).
Conclusion
A FA composition reflecting high intake of saturated fat and a high SCD-1 index is
independently related to CRP concentrations, but not to other markers of inflammation
and endothelial function in this population of elderly men and women. Given the absent
association between FA composition and the other markers, CRP may be the preferable
marker to use when investigating potential relationships between FAs and low-grade
inflammation.
Keywords
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Article info
Publication history
Published online: August 07, 2008
Accepted:
June 21,
2008
Received in revised form:
June 12,
2008
Received:
January 14,
2008
Identification
Copyright
© 2008 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
