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Authors’ reply: Lack of association of chromosome 9p21.3 genotype with cardiovascular function in persons with stable coronary artery disease: The Heart and Soul Study

      Dondona and Stewart point out that the negative findings of our study were restricted to individuals with stable coronary artery disease, and cannot be freely extrapolated to the population at large [
      • Farzaneh-Far R.
      • Na B.
      • Schiller N.B.
      • Whooley M.A.
      Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: the Heart and Soul Study.
      ]. They also suggest that such restriction may have limited our chances of detecting a significant association. We completely agree that the lack of association of 9p21.3 genotype with cardiovascular structure and function cannot be generalized beyond patients with stable coronary artery disease. However, we also draw attention to the fact that other studies of emerging biomarkers in the Heart and Soul Study cohort have comfortably detected significant functional and prognostic associations [
      • Bibbins-Domingo K.
      • Gupta R.
      • Na B.
      • et al.
      N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease.
      ,
      • Ix J.H.
      • Chertow G.M.
      • Shlipak M.G.
      • et al.
      Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study.
      ,
      • Farzaneh-Far R.
      • Cawthon R.M.
      • Na B.
      • et al.
      Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data From the Heart and Soul Study.
      ], reflecting the significant variability in coronary artery disease severity among participants.

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      References

        • Farzaneh-Far R.
        • Na B.
        • Schiller N.B.
        • Whooley M.A.
        Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: the Heart and Soul Study.
        Atherosclerosis. 2009; 205: 492-496
        • Bibbins-Domingo K.
        • Gupta R.
        • Na B.
        • et al.
        N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), cardiovascular events, and mortality in patients with stable coronary heart disease.
        JAMA. 2007; 297: 169-176
        • Ix J.H.
        • Chertow G.M.
        • Shlipak M.G.
        • et al.
        Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study.
        Circulation. 2007; 115: 2533-2539
        • Farzaneh-Far R.
        • Cawthon R.M.
        • Na B.
        • et al.
        Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data From the Heart and Soul Study.
        Arterioscler Thromb Vasc Biol. 2008; 28: 1379-1384
        • Roberts R.
        A customized genetic approach to the number one killer: coronary artery disease.
        Curr Opin Cardiol. 2008; 23: 629-633
        • Jakobsdottir J.
        • Gorin M.B.
        • Conley Y.P.
        • Ferrell R.E.
        • Weeks D.E.
        Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers.
        PLOS Genet. 2009; 5
        • Chen S.N.
        • Ballantyne C.M.
        • Gotto A.M.
        • Marian A.J.
        The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis.
        BMC Cardiovasc Disord. 2009; 27: 3
        • Paynter N.P.
        • Chasman D.I.
        • Buring J.E.
        • et al.
        Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3.
        Ann Intern Med. 2009; 150: 65-72