Abstract
Objective
An increase of FVII activity (FVIIc) has been proposed to be an independent cardiovascular
risk factor. Whether FVII is associated with insulin resistance in coronary heart
disease (CHD) is still unknown. We tested the hypothesis that plasma FVII activity
and leptin are associated with insulin resistance independently.
Methods
We studied 130 subjects, of which 65 were CHD subjects and 65 were non-CHD control
subjects. Fasting plasma levels of leptin, insulin, glucose, FVIIc activity, fibrinogen,
lipid parameters were estimated for all the subjects. Body mass index (BMI), waist
circumference (WC) and blood pressure levels were also determined.
Results
We observed significantly raised plasma levels of FVIIc activity, leptin and insulin
resistance among the CHD subjects compared to the non-CHD subjects. Raised FVIIc activity
levels in CHD were significantly positively correlated with insulin resistance. Raised
plasma leptin levels in CHD were correlated with insulin resistance, BMI and WC. Multivariate
regression analysis showed that elevated levels of FVII activity in CHD was significantly
associated with insulin resistance, independent of dyslipidemia, leptin, blood pressure
levels, BMI, WC, gender and age. Furthermore, raised leptin levels in CHD subjects
were significantly associated with insulin resistance and BMI, independently of each
other and of dyslipidemia, FVIIc, blood pressure levels, WC, gender and age.
Conclusion
Raised FVII and leptin levels in CHD patients were independently associated with insulin
resistance, this was not observed among the non-CHD subjects.
Keywords
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Article info
Publication history
Published online: September 25, 2009
Accepted:
August 23,
2009
Received in revised form:
July 15,
2009
Received:
January 27,
2009
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
