Abstract
Objective
Apolipoprotein E (ApoE) genotype has been associated with systemic inflammation and athero-thrombosis however
the association with abdominal aortic aneurysm (AAA) has not been previously examined.
We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP).
Methods
Serum concentrations of CRP (in 1358 men) and 6 single nucleotide polymorphisms (SNPs)
for ApoE (in 1711 men) were examined in subjects from the Health In Men Study. 640 men with
small AAAs were followed by ultrasound surveillance for a mean of 4.1 years.
Results
There was no association between ApoE genotype and AAA presence. Men heterozygote for the ApoE p.Arg176Cys polymorphism
had slower AAA growth, odds ratio for AAA progression ≥ median 0.41, 95% confidence intervals 0.21–0.80, p = 0.01. Men heterozygote for the ApoE g.50093756A > G polymorphism had slightly more rapid AAA growth, odds ratio for AAA progression ≥ median 1.48, 95% confidence intervals 1.02–2.14, p = 0.04. None of the ApoE SNPs were associated with AAA growth however taking into account multiple testing.
Two SNPs in ApoE were associated with serum CRP under a co-dominant model, ApoE p.Cys130Arg (SNP ID
rs429358), p = 0.00003 and ApoE g.50114786A > G (SNP ID rs4420638), p = 0.00013. Adjusting for other risk factors plus serum creatinine the ɛ4 allele was
associated with lower serum CRP under a dominant model, coefficient 0.089, p = 0.002.
Conclusion
We found no consistent association between ApoE genotype and AAA. We confirmed an association between ApoE genotype and serum CRP.
Keywords
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Article info
Publication history
Published online: October 12, 2009
Accepted:
September 18,
2009
Received in revised form:
September 10,
2009
Received:
July 7,
2009
Identification
Copyright
© 2009 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
