Abstract
Objective
The aim of the present study was to examine the relation between monocyte subsets
and the presence, extent, and vulnerability characteristics of non-calcified coronary
plaques (NCPs) as assessed by multidetector computed tomography (MDCT).
Methods
We studied 73 patients with stable angina pectoris who underwent MDCT. Two monocyte
subsets (CD14+CD16− and CD14+CD16+) were measured by flow cytometry. Coronary artery plaques were assessed by 64-slice
MDCT. We defined NCP vulnerability according to the presence of positive remodeling
(remodeling index > 1.05) and/or low CT attenuation plaques (<35 HU).
Results
A total of 40 (55%) patients had identifiable vulnerable plaques. The relative proportion
of CD14+CD16+ monocytes was significantly greater in patients with 1 or multiple vulnerable plaques
than in patients with no vulnerable plaques or control (healthy) subjects. In addition,
the relative proportion of CD14+CD16+ monocytes was positively correlated with remodeling index (r = 0.40, P < 0.01) and negatively correlated with CT attenuation value (r = −0.34, P < 0.01).
Conclusion
The present results suggest that an increased subset of CD14+CD16+ monocytes is related to coronary plaque vulnerability in patients with stable angina
pectoris.
Keywords
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Article info
Publication history
Published online: May 31, 2010
Accepted:
May 2,
2010
Received in revised form:
April 9,
2010
Received:
February 9,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
