Abstract
Objective
The role of inflammatory adipokines has clear mechanistic effects in the promotion
of both DM2 and cardiovascular diseases (CVDs), but it is unknown to what extent atherosclerosis-related
inflammation might promote defects of glucose metabolism. The purpose of this study
was to test the hypothesis that in subjects with atherosclerotic vascular disease
and no previous medical record of type 2 diabetes mellitus (DM2), the diagnosis of
occult impaired glucose regulation (IGR) is related to the severity of atherosclerosis,
measured as the single or combined presence of an history of coronary artery disease
(CAD), carotid atherosclerosis (Car-ATS) and peripheral artery disease (PAD).
Methods
In a population of 551 subjects (440 men and 111 women) with a previous history of
atherosclerosis, we investigated the presence of IGR (including both impaired glucose
tolerance and DM2). To test the correlation between conventional and non-conventional
risk factors for cardiovascular disease and diabetes we used logistic and regression
analysis models.
Results
IGR was more prevalent in patients with a documented vascular disease in two or three
vessel districts compared with patients with only one symptomatic district (p = 0.016). Among classic risk factors we found that waist circumference was correlated
neither to IGR nor to symptomatic vascular disease extension. By contrast, adiponectin
level was independently associated to vascular and glucose regulation status (p = 0.012 and p < 0.001, respectively).
Conclusion
In subjects affected by atherosclerotic vascular diseases, the presence of impaired
glucose regulation is associated to the number of vascular districts affected and
to a reduced adiponectin level.
Keywords
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Article info
Publication history
Published online: June 16, 2010
Accepted:
May 10,
2010
Received in revised form:
May 10,
2010
Received:
February 16,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
