Abstract
Objective
The purpose of this study was to investigate the acute effects of dietary whey proteins
on lipids, glucose and insulin, and resting energy expenditure in overweight and obese
post-menopausal women, a population highly susceptible to cardiovascular disease.
Methods
A three-way crossover design study was conducted where 20 overweight or obese, post-menopausal
women were randomised to consume either 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control in conjunction with a breakfast meal. Blood samples were taken
for up to 6 h.
Results
There was no significant change in postprandial incremental area under the curve (AUC)
for total cholesterol, low density lipoprotein, high density lipoprotein, non-esterified
fatty acids, Apo B48, insulin and leptin between groups. However, there was a significant
decrease in the appearance of triglycerides (TG) in the blood by 21% and 27% after
consuming the whey meal compared to control and casein meals, respectively, as measured
by AUC. There was also a significant reduction by 27% and 32% in the AUC for TG:ApoB48
ratio in the whey group compared to the glucose and casein groups, respectively. There
was a significantly lower AUC for blood glucose after the consumption of the whey
and casein meal compared to glucose meal.
Conclusion
These findings suggest that a single dose of whey protein can decrease arterial exposure
to smaller TG-enriched lipoprotein particles compared to the glucose and casein meals
in the postprandial period in overweight and obese, post-menopausal women.
Keywords
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Article info
Publication history
Published online: June 21, 2010
Accepted:
May 22,
2010
Received in revised form:
April 12,
2010
Received:
January 21,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
