Abstract
Objective
We evaluated the temporal association between arterial stiffening and the early stage
of renal functional decline.
Methods
In 2053 Japanese employees with an estimated glomerular filtration rate (GFR) of ≥60 ml/min/1.73 m2 plus no proteinuria (40 ± 8 years old) at the start, brachial-ankle pulse wave velocity (baPWV) and serum C-reactive
protein (CRP) were measured before and after a 5–6-year follow-up period.
Results
After adjusting for confounding variables including serum CRP levels, higher baseline
baPWV was associated with lower follow-up GFR (value expressed as per doubling: −16;
95% confidence interval: −24 to −9; P < 0.01) and with higher annual rate of decline in GFR (value expressed as per doubling:
−3; 95% confidence interval: −4 to −2; P < 0.01). Every m/s higher baPWV was associated with a 36% increased odds (95% CI 1.09–1.70;
P < 0.01) for a development of a GFR <60 ml/min/1.73 m2 at follow-up. In contrast, baseline GFR was not associated with follow-up baPWV (P = 0.08) or the annual rate of change in baPWV (P = 0.11).
Conclusion
In a Japanese occupational cohort with normal renal function/early chronic kidney
disease, elevated arterial stiffness was an independent risk factor for the decline
in renal function. CRP did not appear to exert any significant influence on this association.
Keywords
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Article info
Publication history
Published online: July 01, 2010
Accepted:
May 20,
2010
Received in revised form:
May 20,
2010
Received:
February 14,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
