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Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

  • Author Footnotes
    1 These authors contributed equally to this work.
    Ji Young Kim
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea
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  • Author Footnotes
    1 These authors contributed equally to this work.
    Jean Kyung Paik
    Footnotes
    1 These authors contributed equally to this work.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea
    Search for articles by this author
  • Oh Yoen Kim
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea
    Search for articles by this author
  • Hae Won Park
    Affiliations
    National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea
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  • Jin Hee Lee
    Affiliations
    CJ Food R&D, CJ Corp. Seoul, Republic of Korea
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  • Yangsoo Jang
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    Cardiology Division, Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Republic of Korea

    Severance Medical Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea

    Severance Biomedical Science Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea
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  • Jong Ho Lee
    Correspondence
    Corresponding author at: Department of Food and Nutrition, Yonsei University, 134 Shinchon-Dong, Sudaemun-Gu, Seoul 120-749, Korea. Tel.: +82 2 2123 3122; fax: +82 2 364 9605.
    Affiliations
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea

    National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, Yonsei University, Seoul, Republic of Korea
    Search for articles by this author
  • Author Footnotes
    1 These authors contributed equally to this work.

      Abstract

      Objective

      The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress.

      Methods

      Healthy men (n = 126) were randomized to receive placebo (n = 38), 6 mg (n = 41), or 15 mg (n = 37) lycopene daily for 8-week.

      Results

      Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P < 0.001). The 15 mg/day group had greater increase in plasma SOD activity (P = 0.014) and reduction in lymphocyte DNA comet tail length (P = 0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45 ± 0.09 vs. 1.79 ± 0.12; P = 0.032) in the 15 mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15 mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r = 0.234, P = 0.017) especially in the 15 mg lycopene/day group (r = 0.485, P = 0.003), lymphocyte DNA comet tail moment (r = −0.318, P = 0.001), and hs-CRP (r = −0.238, P = 0.011). In addition, changes in lycopene correlated with hs-CRP (r = −0.230, P = 0.016) and SOD activity (r = 0.205, P = 0.037).

      Conclusion

      An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.

      Keywords

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